Identification of Superficial White Matter Abnormalities in Alzheimer's Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging
Identification of Superficial White Matter Abnormalities in Alzheimer's Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging
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DOI：
10.3233/adr-190149
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发表时间：
2020-01-01
影响因子：
3.2
通讯作者：
Zare, Hoda
中科院分区：
文献类型：
--
作者：
Bigham, Bahare;Zamanpour, Seyed Amir;Zare, Hoda
背景：弥散张量成像(DTI)作为一种基于磁共振成像(MRI)的神经成像技术，可以评估大脑的微结构变化。以往的DTI研究报道了脑部疾病中浅层白质(SWM)结构完整性的降低。目的：本研究旨在利用脑束造影术和感兴趣区(ROI)方法确定阿尔茨海默病(AD)和轻度认知损害(MCI)患者的SWM的扩散特性。方法：从AD神经成像计划(ADNI)数据库下载24例AD患者、24例MCI患者和24名正常对照(NC)的扩散MRI数据。使用DSI Studio软件进行DTI处理。对于基于感兴趣区的分析，首先利用Talairach图谱将浅层白质分为左右额区、顶区、颞区、岛区、边缘区和枕区，然后对每个区域进行100000个粒子的纤维束成像。结果：声带造影术和感兴趣区分析显示，在SWM的大部分区域，三组(p<；0.05)的径向、轴向和平均弥散系数值存在显著差异。此外，在AD组中，简易智力状态检查与顶叶和颞叶SWM的径向、轴向和平均弥散系数值显著相关(p<；0.05)。结论：DTI提供了反映AD和MCI患者SWM微观结构变化的信息。因此，应用DTI技术评估SWM有助于AD和MCI患者的临床诊断。
Background: Diffusion tensor imaging (DTI) estimates the microstructural alterations of the brain, as a magnetic resonance imaging (MRI)-based neuroimaging technique. Prior DTI studies reported decreased structural integrity of the superficial white matter (SWM) in the brain diseases.Objective: This study aimed to determine the diffusion characteristics of SWM in Alzheimer's disease (AD) and mild cognitive impairment (MCI) using tractography and region of interest (ROI) approaches.Methods: The diffusion MRI data were downloaded from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database on 24 patients with AD, 24 with MCI, and 24 normal control (NC) subjects. DTI processing was performed using DSI Studio software. First, for ROI-based analysis, The superficial white matter was divided into right and left frontal, parietal, temporal, insula, limbic and occipital regions by the Talairach Atlas, Then, for tractography-based analysis, the tractography of each of these regions was performed with 100000 seeds. Finally, the average diffusion values were extracted from voxels within the ROIs and tracts.Results: Both tractography and ROI analyses showed a significant difference in radial, axial and mean diffusivity values between the three groups (p < 0.05) across most of the SWM. Furthermore, The Mini-Mental State Examination was significantly correlated with radial, axial, and mean diffusivity values in parietal and temporal lobes SWM in the AD group (p < 0.05).Conclusion: DTI provided information indicating microstructural changes in the SWM of patients with AD and MCI. Therefore, assessment of the SWM using DTI may be helpful for the clinical diagnosis of patients with AD and MCI.