Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes.
Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes.
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DOI：
10.3389/fnagi.2016.00184
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发表时间：
2016
影响因子：
4.8
通讯作者：
Smith JC
中科院分区：
文献类型：
--
作者：
Alfini AJ;Weiss LR;Leitner BP;Smith TJ;Hagberg JM;Smith JC
虽然耐力运动训练可以改善脑血管健康并对海马体产生神经营养作用，但停止这项运动对大脑的影响仍不清楚。我们的目的是测量 10 天的停止训练对健康和身体健康的老年人灰质和海马的静息脑血流量 (rCBF) 的影响。我们假设运动训练停止 10 天后，海马体的 rCBF 会下降。从当地跑步俱乐部招募了 12 名优秀运动员，他们被定义为具有长期耐力训练历史（≥15 年）的老年人（年龄≥50 岁）。筛选后，符合条件的参与者被要求连续 10 天停止所有训练和剧烈体力活动。在运动停止期之前和之后立即使用灌注加权 MRI 测量 rCBF。对灰质进行体素分析，并预先选择海马作为结构定义的感兴趣区域 (ROI)，以检测 rCBF 随着时间的变化。八个灰质脑区的静息 CBF 显着下降。这些区域包括：(L) 颞下回、梭状回、顶下小叶、(R) 小脑扁桃体、舌回、楔前叶和双侧小脑 (FWE p < 0.05)。此外，10天没有运动训练后，左右海马内的rCBF显着下降。这些发现表明，脑血管系统，包括静息海马血流的调节，对高水平运动员运动训练的短期减少有反应。身体健康的人停止运动训练可能提供一种新方法来评估急性运动和运动训练对老年人大脑功能的影响。
While endurance exercise training improves cerebrovascular health and has neurotrophic effects within the hippocampus, the effects of stopping this exercise on the brain remain unclear. Our aim was to measure the effects of 10 days of detraining on resting cerebral blood flow (rCBF) in gray matter and the hippocampus in healthy and physically fit older adults. We hypothesized that rCBF would decrease in the hippocampus after a 10-day cessation of exercise training. Twelve master athletes, defined as older adults (age ≥ 50 years) with long-term endurance training histories (≥15 years), were recruited from local running clubs. After screening, eligible participants were asked to cease all training and vigorous physical activity for 10 consecutive days. Before and immediately after the exercise cessation period, rCBF was measured with perfusion-weighted MRI. A voxel-wise analysis was used in gray matter, and the hippocampus was selected a priori as a structurally defined region of interest (ROI), to detect rCBF changes over time. Resting CBF significantly decreased in eight gray matter brain regions. These regions included: (L) inferior temporal gyrus, fusiform gyrus, inferior parietal lobule, (R) cerebellar tonsil, lingual gyrus, precuneus, and bilateral cerebellum (FWE p < 0.05). Additionally, rCBF within the left and right hippocampus significantly decreased after 10 days of no exercise training. These findings suggest that the cerebrovascular system, including the regulation of resting hippocampal blood flow, is responsive to short-term decreases in exercise training among master athletes. Cessation of exercise training among physically fit individuals may provide a novel method to assess the effects of acute exercise and exercise training on brain function in older adults.