PATTERNS OF NUCLEOTIDE COMPOSITION AT FOURFOLD DEGENERATE SITES OF ANIMAL MITOCHONDRIAL GENOMES
PATTERNS OF NUCLEOTIDE COMPOSITION AT FOURFOLD DEGENERATE SITES OF ANIMAL MITOCHONDRIAL GENOMES
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DOI：
10.1007/bf01215182
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发表时间：
1995-09-01
影响因子：
3.9
通讯作者：
KOCHER, TD
中科院分区：
文献类型：
--
作者：
PERNA, NT;KOCHER, TD
三种统计量（%GC，CC-偏斜和AT-偏斜）可用于描述DNA序列中核苷酸组成的总体模式。分析了16种动物线粒体基因组的四重简并第三密码子位置。总的组成，如%GC所测量的，从蜜蜂的3.6% GC到人类mtDNA的47.2% GC不等。线粒体基因组链之间的组成差异进行了量化，使用本文提出的两个偏斜统计。链特异性分布的基地之间的动物类群独立的整体%GC。成分模式反映了替代过程。这些模式的描述可能有助于形成有关替代机制的假说。
Three statistics (%GC, CC-skew, and AT-skew) can be used to describe the overall patterns of nucleotide composition in DNA sequences. Fourfold degenerate third codon positions from 16 animal mitochondrial genomes were analyzed. The overall composition, as measured by %GC, varies from 3.6 %GC in the honeybee to 47.2 %GC in human mtDNA. Compositional differences between strands of the mitochondrial genome were quantified using the two skew statistics presented in this paper. Strand-specific distribution of bases varies among animal taxa independently of overall %GC. Compositional patterns reflect the substitution process. Description of these patterns may aid in the formation of hypotheses about substitutional mechanisms.