Quality of life in 1931 adult patients with epilepsy: Seizures do not tell the whole story
Quality of life in 1931 adult patients with epilepsy: Seizures do not tell the whole story
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DOI：
10.1016/j.yebeh.2011.08.039
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发表时间：
2011-12-01
影响因子：
2.6
通讯作者：
Najm, Imad
中科院分区：
文献类型：
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作者：
Jehi, Lara;Tesar, George;Najm, Imad
目的：这里所描述的工作的目的是表征生活质量（QOL）及其决定因素在一个大的队列的成年patients with epilepsy.Methods：验证措施反映疾病的严重程度和心理社会功能，电子收集在2009年看到的所有门诊病人。多变量回归调整重复测量确定的决定因素的生活质量，定义的癫痫生活质量问卷-10（QOLIE-10）。结果：七千七百八十四次访问癫痫患者被确定。调查问卷完成率为77%，产生了对应于1931例个体患者的5960条记录用于分析。在多变量建模后，两个最具临床意义的QOL预测因子是癫痫严重程度（如果LSSS>40，则平均QOLIE-10评分= 28.8，否则为19.2）和抑郁（如果PHQ-9 >= 10，则平均QOLIE-10评分= 31.7，否则为19.3）。收集经验证的健康状况措施，改善病人的管理是可能的设置内的常规临床护理。(C)2011 Elsevier Inc. All rights reserved.
Objective: The aim of the work described here was to characterize quality of life (QOL) and its determinants in a large cohort of adult patients with epilepsy.Methods: Validated measures reflecting disease severity and psychosocial functioning were electronically collected on all outpatients seen during 2009. Multivariate regression adjusting for repeated measures identified determinants of QOL, as defined by the Quality of Life in Epilepsy Questionnaire-10 (QOLIE-10).Results: Seven thousand seven hundred eighty-four visits from patients with epilepsy were identified. The questionnaire completion rate was 77%, yielding 5960 records corresponding to 1931 individual patients for analysis. Following multivariate modeling, the two most clinically significant QOL predictors were seizure severity (mean QOLIE-10 score = 28.8 if LSSS>40 vs 19.2 otherwise) and depression (mean QOLIE-10 score = 31.7 if PHQ-9 >= 10 vs 19.3 otherwise).Conclusions: Optimizing quality of life in patients with epilepsy requires an approach that extends beyond controlling seizures. Collection of validated health status measures improving patient management is possible within the setting of routine clinical care. (C) 2011 Elsevier Inc. All rights reserved.