Glutamate transporters in neurologic disease
Glutamate transporters in neurologic disease
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DOI：
10.1001/archneur.58.3.365
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发表时间：
2001-03-01
影响因子：
--
通讯作者：
Rothstein, JD
中科院分区：
文献类型：
--
作者：
Maragakis, NJ;Rothstein, JD
谷氨酸是人脑中主要的兴奋性氨基酸神经递质。它在突触可塑性、学习和发育中很重要。它在突触间隙的活性通过受体失活和谷氨酸再摄取来小心地平衡。当这种平衡被打破时，过量的谷氨酸本身就可能成为神经毒性。
Glutamate is the primary excitatory amino acid neurotransmitter in the human brain. It is important in synaptic plasticity, learning, and development. Its activity at the synaptic cleft is carefully balanced by receptor inactivation and glutamate reuptake. When this balance is upset, excess glutamate can itself become neurotoxic.