Effects of blockade of the endothelin receptor A and inhibition of nitric oxide synthesis on uteroplacental and renal blood flow in awake pregnant rats
Effects of blockade of the endothelin receptor A and inhibition of nitric oxide synthesis on uteroplacental and renal blood flow in awake pregnant rats
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DOI：
10.1016/j.ajog.2004.04.035
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发表时间：
2005-01-01
影响因子：
9.8
通讯作者：
Jansson, T
中科院分区：
文献类型：
--
作者：
Ajne, G;Nisell, H;Jansson, T
目的：探讨ETA受体和一氧化氮(NO)在妊娠大鼠子宫胎盘和肾脏血流调节中的作用。研究设计：用微球测量局部血流。孕期23天的SD-Dawley大鼠妊娠技术。结果：BQ-123可显著增加胎盘和子宫肌层血流量，分别增加胎盘和子宫肌层血流量80%和35%。BQ-123不改变肾血流量。输注L对胎盘及子宫肌层血流无明显影响。既不是在19号公路，也不是21号公路。结论：内源性ET在大鼠子宫胎盘血流调节中起重要作用。一氧化氮有助于显著的血管扩张。肾血管系统：然而。NO似乎不参与清醒妊娠大鼠子宫胎盘血流的维持。(C)2005 Elsevier Inc.保留所有权利。
Objective: The aim of this study was to evaluate the role or the ETA receptor and nitric oxide (NO) in the regulation Of Uteroplacental and renal blood flow in pregnant rats.Study design: Regional blood flows were measured by the microsphere. technique in pregnant Sprague-Dawley rats (term 23 days). Blood flow was measured before and after ETA receptor blockade (BQ-123 1 mg/kg) at gestational day (GD) 19 or 21 (n = 8 and n = 9: respectively,)In 2 additional groups blood flow was measured before and after NO synthase inhibition (L-NAME 2 mug/min) at GD 19 or 21 (n = 10 in each group).Results: BQ-123 significantly increased placental and myometrial blood flows, by almost 80% and 35%, respectively, at both gestational ages. BQ-123 did not alter renal blood flow. No effect on placental or myometrial blood flow was observed after L-NAME infusion. neither at GD 19 nor GD 21. Renal blood flow decreased by nearly 35% in both groups after L-NAME.Conclusion: There is an important role for endogenous ET in the regulation of uteroplacental blood flow in the rat. NO contributes to a significant vasodilatation in the. renal vasculature: however. NO appears not to be involved in the maintenance of uteroplacental blood flow in the awake pregnant rat. (C) 2005 Elsevier Inc. All rights reserved.