Expression of the 78 kD glucose-regulated protein is induced by endoplasmic reticulum stress in the development of hepatopulmonary syndrome.
Expression of the 78 kD glucose-regulated protein is induced by endoplasmic reticulum stress in the development of hepatopulmonary syndrome.
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DOI：
10.1016/j.gene.2013.11.065
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发表时间：
2014-03-01
期刊：
影响因子：
3.5
通讯作者：
Ji C
中科院分区：
文献类型：
--
作者：
Zhang H;Lv M;Jia J;Zhao Z;Zhang L;Lai L;Wu Y;Li B;Li C;Ji J;Tian X;Liu Y;Li X;Pang H;Guo J;Wang L;Fan Y;Zhang C;Han D;Ji C
This study is to explore the role of 78 kD glucose-regulated protein (GRP78) in development of hepatopulmonary syndrome (HPS) in rats. The rat model of liver cirrhosis and HPS were induced with multiple pathogenic factors. Hematoxylin and eosin (H & E) staining was performed to detect the pathological changes of the lung and liver tissues. The levels of alanine transferase (ALT), endotoxin, and tumor necrosis factor-α (TNF-α) in plasma and TNF-α and malondialdehyde (MDA) in lung tissues were detected. RT-PCR and Western blotting were conducted to detect the mRNA and protein expression levels of GRP78 in lungs. The plasma endotoxin level was gradually increased as HPS developed, and the mRNA and protein expression levels of GRP78 in lungs were also increased as the disease progressed. The levels of ALT and TNF-α in plasma and the contents of TNF-α and MDA in lung tissues were gradually increased along with the disease progression, with a strong positive correlation. Compared with controls, the plasma TNF-α level and the mRNA and protein expression levels of GRP78 in lung tissues were significantly higher in rats with HPS. The levels of endotoxin and ALT in plasma and the level of MDA in lungs were significantly higher in rats with HPS than controls. The increased GRP78 expression is indicative of endoplasmic reticulum stress response during HPS, which may play an important role in the disease pathogenesis.
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DOI：
10.1016/j.bbrc.2008.05.036
发表时间：
2008-07-18
影响因子：
3.1
作者：
Kimura, Kenya;Ito, Sachiko;Isobe, Ken-ichi
通讯作者：
Isobe, Ken-ichi
影响因子：
13.5
作者：
Ji, Cheng;Kaplowitz, Neil;Lau, Mo Yin;Kao, Eddy;Petrovic, Lydia M.;Lee, Amy S.
通讯作者：
Lee, Amy S.
影响因子：
5.8
作者：
Güngör N;Pennings JL;Knaapen AM;Chiu RK;Peluso M;Godschalk RW;Van Schooten FJ
通讯作者：
Van Schooten FJ
通过 ES-TRAP 实时检测和连续监测体外和体内 ER 应激：内毒素血症期间全身、短暂 ER 应激的证据。
影响因子：
14.9
作者：
Hiramatsu N;Kasai A;Hayakawa K;Yao J;Kitamura M
通讯作者：
Kitamura M
DOI：
10.1111/j.1440-1746.2007.05276.x
发表时间：
2008-03-01
影响因子：
4.1
作者：
Ji, Cheng
通讯作者：
Ji, Cheng