Episodic Future Thinking Reduces Reward Delay Discounting through an Enhancement of Prefrontal-Mediotemporal Interactions
Episodic Future Thinking Reduces Reward Delay Discounting through an Enhancement of Prefrontal-Mediotemporal Interactions
复制标题
DOI：
10.1016/j.neuron.2010.03.026
复制
发表时间：
2010-04-15
期刊：
影响因子：
16.2
通讯作者：
Buechel, Christian
中科院分区：
文献类型：
--
作者：
Peters, Jan;Buechel, Christian
随着时间的推移，人类对未来回报的价值不屑一顾。在这里，我们使用功能磁共振成像(FMRI)和神经耦合分析表明，间歇性未来思维通过调制神经决策和间歇性未来思维网络来降低延迟贴现率。除了标准的控制条件外，在延迟折扣任务中，还呈现了真实的特定于受试者的事件线索。在线索处理过程中自发的情节意象预测了受试者在多大程度上改变了他们的偏好，倾向于更着眼于未来的选择行为。前扣带回皮质的神经评估信号以及该区域与海马体和杏仁体的功能耦合预测了未来思维对个人偏好功能的调节程度。第二个实验复制了行为效应，并排除了其他解释，如基于日期的处理和时间焦点。目前的数据揭示了一种机制，通过这种机制，神经决策和展望网络可以相互作用，产生着眼于未来的选择行为。
Humans discount the value of future rewards over time. Here we show using functional magnetic resonance imaging (fMRI) and neural coupling analyses that episodic future thinking reduces the rate of delay discounting through a modulation of neural decision-making and episodic future thinking networks. In addition to a standard control condition, real subject-specific episodic event cues were presented during a delay discounting task. Spontaneous episodic imagery during cue processing predicted how much subjects changed their preferences toward more future-minded choice behavior. Neural valuation signals in the anterior cingulate cortex and functional coupling of this region with hippocampus and amygdala predicted the degree to which future thinking modulated individual preference functions. A second experiment replicated the behavioral effects and ruled out alternative explanations such as date-based processing and temporal focus. The present data reveal a mechanism through which neural decision-making and prospection networks can interact to generate future-minded choice behavior.