Resting-State Brain Activity in Schizophrenia and Major Depression: A Quantitative Meta-Analysis
Resting-State Brain Activity in Schizophrenia and Major Depression: A Quantitative Meta-Analysis
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DOI：
10.1093/schbul/sbr151
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发表时间：
2013-03-01
影响因子：
6.6
通讯作者：
Gallinat, Juergen
中科院分区：
文献类型：
--
作者：
Kuehn, Simone;Gallinat, Juergen
静息状态下大脑的内在活动不是随机的，目前被认为是自我参照加工的神经反射。精神分裂症作为一种自我障碍，自我参照通常会减少，而广泛的自我归因，如消极思想是重性抑郁症的特征。然而，缺乏针对这两种疾病的静息态脑活动的定量荟萃分析。在这里，我们主要预测与自我参照处理相关的大脑区域的异常静息态活动。通过激活似然估计（ALE）的功能磁共振成像和正电子发射断层扫描的研究，我们调查了同时发生的高激活和低激活的静息状态测量精神分裂症和抑郁症患者与健康对照组相比。结果发现，精神分裂症患者的腹内侧前额叶皮层（vmPFC）、左侧海马、后扣带回、下楔前叶和楔前叶存在低激活，双侧舌回存在高激活。在重性抑郁症中，我们发现vmPFC、左侧腹侧纹状体和左侧丘脑过度激活，而左侧中央后回、左侧梭状回和左侧丘脑低激活。整体ALE分析证实了精神分裂症患者VMPFC的低激活和抑郁症患者VMPFC的高激活的接近性。这两种疾病的VMPFC的相反的静息态活动与精神分裂症和抑郁症的核心特征功能障碍性自我参照的不同表达一致。vmPFC先前已被确定为自我参照处理的一个关键区域，并可能代表一个目标，以增加静息状态活动的诊断有效性与自我功能障碍的疾病。
Intrinsic activity of the brain during resting-state is not random and is currently discussed as a neural reflection of self-referential processing. Self-reference is typically reduced in schizophrenia as a disorder of the self while extensive self-attribution of, eg, negative thoughts is characteristic for major depression. However, a quantitative meta-analysis targeting the resting-state brain activity in both disorders is lacking. Here, we predict primarily abnormal resting-state activity in brain regions related to self-referential processing. By means of activation likelihood estimation (ALE) on functional magnetic resonance imaging and positron emission tomography studies, we investigated concurrence of hyperactivation and hypoactivation in resting-state measurements of schizophrenic and depressed patients compared with healthy controls. We found hypoactivation in ventromedial prefrontal cortex (vmPFC), left hippocampus, posterior cingulate cortex, lower precueus and the precuneus, and hyperactivation in bilateral lingual gyrus of schizophrenic patients. In major depression, we found hyperactivation in vmPFC, left ventral striatum, and left thalamus and hypoactivation in left postcentral gyrus, left fusiform gyms, and left insula. An overall ALE analysis confirmed the proximity of hypoactivation in schizophrenia and hyperactivation in major depression in the vmPFC.The opposing resting-state activity in vmPFC for the 2 disorders is in line with the different expression of dysfunctional self-reference as core characteristics of schizophrenia and major depression. The vmPFC has previously been identified as a crucial area for self-referential processing and may represent a target to increase the diagnostic validity of resting-state activity for disorders with dysfunctions of the self.