Immune complex levels in children with severe Plasmodium falciparum malaria
Immune complex levels in children with severe Plasmodium falciparum malaria
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DOI：
10.4269/ajtmh.2005.72.593
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发表时间：
2005-05-01
影响因子：
3.3
通讯作者：
Stoute, JA
中科院分区：
文献类型：
--
作者：
Mibei, EK;Orago, ASS;Stoute, JA
疟疾感染导致循环免疫复合物的形成。然而，这些复合物是否在复杂恶性疟原虫疟疾的发病机制中发挥作用尚不清楚。这项研究旨在确定患有严重疟疾相关贫血和脑型疟疾的儿童之间以及这两组儿童及其各自的无并发症症状疟疾之间的免疫复合物水平是否存在差异。或者健康的无症状控制组。患有严重疟疾相关贫血和脑型疟疾的儿童的免疫复合物水平明显高于各自的对照组，但在两个严重疟疾组之间的水平没有显著差异。此外，在严重贫血对照组中，血红蛋白水平与免疫复合物水平呈反比关系。提示免疫复合物可能有助于这些儿童的红细胞破坏。这些结果表明，免疫复合物水平本身不能解释严重疟疾相关贫血和脑型疟疾之间不同临床表现的差异。
Malaria infection leads to the formation of circulating immune complexes. However, it is unclear whether these complexes play a role in the pathogenesis of complicated Plasmodium falciparum malaria. This study aimed at determining if there are differences in the levels of immune complexes between children with severe malaria-associated anemia and cerebral malaria and between each of these two groups and their respective uncomplicated symptomatic malaria. or healthy asymptomatic controls. Children with severe malaria-associated anemia and cerebral malaria had significantly higher immune complex levels than their respective controls, but there were no significant differences in the levels between the two severe malaria groups. In addition, there was an inverse relationship between the hemoglobin levels end immune complex levels in the severe anemia controls. suggesting that immune complexes may contribute to erythrocyte destruction in these children. These results suggest that immune complex levels alone cannot account for the differences in the distinct clinical presentation between severe malaria-associated anemia and cerebral malaria.