Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging
Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging
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DOI：
10.1016/s0304-3940(02)01367-8
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发表时间：
2003-02-27
影响因子：
2.5
通讯作者：
Sartor, K
中科院分区：
文献类型：
--
作者：
Hartmann, M;Heiland, S;Sartor, K
为了评估灌注加权回波平面磁共振成像在原发性幕上淋巴瘤（PCNSL）和胶质母细胞瘤（GBM）鉴别诊断中的有用性，使用1.5 T磁共振（MR）成像仪对12例PCNSL和12例GBM患者进行了检查。利用动态磁敏感对比MR成像分析每个肿瘤的强度-时间曲线，并确定相对区域脑血容量比（rrCBV [肿瘤/对侧白色物质（WM）]），以了解这些参数是否可用于区分PCNSL和GBM。PCNSL的最大rrCBV比值显著低于GBM（P < 0.0001）。比较两个肿瘤组的强度-时间曲线，PCNSL显示了一种特征性曲线类型，由于造影剂大量泄漏到间质间隙中，信号强度显著增加，高于基线。PCNSL倾向于具有较低的最大CBV比和典型的强度-时间曲线。这两个参数可能有助于区分PCNSL和GBM。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
To assess the usefulness of perfusion-weighted echo-planar magnetic resonance imaging in the differential diagnosis of primary supratentorial lymphoma (PCNSL) and glioblastoma (GBM), 12 patients with a PCNSL and 12 with a GBM were examined using a 1.5 T magnetic resonance (MR) imager. With dynamic-susceptibility contrast MR imaging the intensity-time curves of each tumor were analyzed, and we determined the relative regional cerebral blood volume ratios (rrCBV [tumor/contralateral white matter (WM)]) to find out whether these parameters could be used to separate PCNSL from GBM. The maximum rrCBV ratio in the PCNSL was significantly lower than that of the GBM (P < 0.0001). Comparing the intensity-time curves for the two tumor groups, the PCNSL showed a characteristic type of curve with a significant increase in signal intensity above the baseline due to massive leakage of contrast media into the interstitial space. PCNSL tend to have low maximum CBV ratios and typical intensity-time curves. These two parameters may be useful in distinguishing PCNSL from GBM. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.