Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.
Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.
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DOI：
10.1007/s11684-012-0216-4
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发表时间：
2012-09-01
影响因子：
8.1
通讯作者：
Feng, Gen-Sheng
中科院分区：
文献类型：
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作者：
Li, Shuangwei;Hsu, Diane DiFang;Feng, Gen-Sheng
PTPN 11编码酪氨酸磷酸酶Shp 2，是介导细胞对激素和细胞因子反应的关键基因。与最初预测的酪氨酸磷酸酶的肿瘤抑制基因不同，PTPN 11首先被鉴定为原癌基因，因为该基因的激活突变与白血病发生相关。然而，最近的实验数据表明PTPN 11/Shp 2在肝癌发生中起肿瘤抑制剂的作用。本文就PTPN 11/Shp 2基因在不同细胞类型中的促癌或抑癌作用作一综述。
PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.