White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study
White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study
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DOI：
10.1016/s0925-4927(00)00082-2
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发表时间：
2001-02-28
影响因子：
2.3
通讯作者：
Lim, KO
中科院分区：
文献类型：
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作者：
Pomara, N;Crandall, DT;Lim, KO
弥漫性白质苍白是HIV-1感染最常见的神经病理特征，已被发现在疾病的晚期尤为突出。这项研究的目的是确定在医学上稳定的、非卧床的HIV-1患者中是否可以检测到细微的白质异常。在体内，使用扩散张量成像(DTI)。DTI是一种磁共振成像(MRI)技术，特别适用于研究细微的白质异常。对6名HIV-1患者和9名对照进行了DTI检查。这两组人的年龄相似。HIV-1患者额叶和内囊的白质存在异常的分数各向异性。在平均扩散系数没有组别差异的情况下，计算质子密度。并计算出T2。在HIV-1疾病中，DTI可能比传统的MRI方法更敏感地检测到细微的白质破坏。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Diffuse white matter pallor is the most frequent neuropathological feature of HIV-1 infection and has been found to be particularly prominent in the advanced stages of the disease. The purpose of this study was to determine whether subtle white matter abnormalities can be detected in medically stable, ambulatory HIV-1 patients. in vivo, using diffusion tensor imaging (DTI). DTI is a magnetic resonance imaging (MRI) technique that is uniquely suited for the study of subtle white matter abnormalities. DTI was performed in six HIV-1 patients and nine controls. The two groups were similar in age. Abnormal fractional anisotropy was found in the white matter of the frontal lobes and internal capsules of the HIV-1 patients. in the absence of group differences in mean diffusivity, computed proton density. and computed T2. DTI may be more sensitive than conventional MRI methods for detecting subtle white matter disruptions, in HIV-1 disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.