PEG2-Induced Pyroptosis Regulates the Expression of HMGB1 and Promotes hEM15A Migration in Endometriosis.
PEG2-Induced Pyroptosis Regulates the Expression of HMGB1 and Promotes hEM15A Migration in Endometriosis.
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PEG2诱导的子宫内膜异位症细胞凋亡调节HMGB1表达并促进hEM15A迁移
DOI：
10.3390/ijms231911707
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发表时间：
2022-10-03
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Endometriosis (EMS) is a common gynecological disease. Prostaglandin E2 (PGE2), which induces chronic pelvic inflammation and cell pyroptosis, a form of programmed cell death based on inflammasome activation, are involved in EMS, but the extent of their involvement and roles remain unclear. The present study aimed to evaluate PGE2-induced pyroptosis in EMS and the influence of PGE2 in EMS progression. Using western blotting, it was found that the expressions of PGE2 and pyroptosis-related proteins (NLRP3, cleaved caspase-1, interleukin (IL)-1β and IL-18) were higher in EMS tissues than in normal endometrial tissues. The levels of PGE2, IL-1β, and IL-18 in the serum of patients with EMS and cell culture fluids were also detected. Using the transwell assay, we verified that PGE2 promoted hEM15A migration via the NLRP3/caspase-1 pyroptotic pathway, and PGE2-induced pyroptosis upregulated the expressions of high mobility group box 1 (HMGB1), E-cadherin, and vimentin. Immunohistochemistry analysis confirmed that PGE2-induced pyroptosis contributed to EMS invasion. These results suggest that PGE2-induced pyroptosis affects the progression of EMS by changing the migration ability of pyroptotic cells and upregulating the expression of HMGB1, E-cadherin, and vimentin. Our findings provide crucial evidence for new treatment pathways and use of anti-inflammatory drugs in EMS.
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影响因子：
4
作者：
Zhou L;Yao L;Dai L;Zhu H;Ye X;Wang S;Cheng H;Ma R;Liu H;Cui H;Chang X
通讯作者：
Chang X
PEITC 直接抑制 GSDMD 可减少小鼠肝细胞焦亡并减轻急性肝损伤。
影响因子：
7.3
作者：
Wang J;Shi K;An N;Li S;Bai M;Wu X;Shen Y;Du R;Cheng J;Wu X;Xu Q
通讯作者：
Xu Q
影响因子：
5.6
作者：
Parra-Herran, Carlos;Bassiouny, Dina;Nofech-Mozes, Sharon
通讯作者：
Nofech-Mozes, Sharon
中国卵巢子宫内膜样癌患者中常见 POLE1 p.S297F 突变
DOI：
10.1016/j.mrfmmm.2014.01.003
发表时间：
2014-03-01
影响因子：
2.3
作者：
Zou, Yang;Liu, Fa-Ying;He, Ming
通讯作者：
He, Ming
影响因子：
4.7
作者：
Nisar MA;Zheng Q;Saleem MZ;Ahmmed B;Ramzan MN;Ud Din SR;Tahir N;Liu S;Yan Q
通讯作者：
Yan Q