Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome.
Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome.
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DOI：
10.3390/nu14214660
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发表时间：
2022-11-04
期刊：
影响因子：
5.9
通讯作者：
Jain, Ajay K.
中科院分区：
文献类型：
--
作者：
Bettag, Jeffery;Po, Loren;Cunningham, Cassius;Tallam, Rahul;Kurashima, Kento;Nagarapu, Aakash;Hutchinson, Chelsea;Morfin, Sylvia;Nazzal, Mustafa;Lin, Chien-Jung;Mathur, Amit;Aurora, Rajeev;Jain, Ajay K.
短肠综合征（SBS）是一种特别严重的疾病，其中小肠不能吸收足够的营养以满足生物需求，如果不治疗，会导致严重疾病和潜在死亡。鉴于肠道在整个身体的许多信号级联中的重要作用，SBS导致许多途径的中断和各种激素的不平衡。由于无法满足足够的营养需求，需要给予静脉营养，即全胃肠外营养（TPN）。然而，TPN存在困难，例如严重肝损伤和继发于持续缺乏管腔内容物的信号改变。本手稿旨在总结TPN对肠-脑、肠-肺和肠-肝轴等系统的全身影响的相关研究，并介绍目前正在使用或研究的新型治疗方法，作为TPN诱导损伤的缓解策略。
Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut–brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury.
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
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作者：
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