A VERY SMALL PORCINE VIRUS WITH CIRCULAR SINGLE-STRANDED-DNA
A VERY SMALL PORCINE VIRUS WITH CIRCULAR SINGLE-STRANDED-DNA
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DOI：
10.1038/295064a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
KOCH, MA
中科院分区：
文献类型：
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作者：
TISCHER, I;GELDERBLOM, H;KOCH, MA
此前有报道称，猪PK-15细胞系(ATCC-CCL31)的培养物长期感染了一种小病毒，推测含有RNA1。在这些培养物中没有观察到明显的细胞病变效应。在寻找持续性病毒感染的体外模型的过程中，对该病原体进行了更详细的研究。研究表明，该病毒的直径为17 nm，含有一个共价闭合的环状单链DNA，相对分子质量为0.58×106，主要衣壳多肽的相对分子质量为3.6万。在接受测试的动物中，只有猪被发现有抗体。根据这些特性，该病毒似乎是迄今为止从未遇到过的动物病毒家族的成员。我们已将该病毒命名为猪圆环病毒(PCV)。
It was reported previously that cultures of the porcine PK-15 cell line (ATCC-CCL31) were chronically infected with a small virus, supposedly containing RNA1. No gross cytopathic effect was seen in these cultures. During the search for anin vitromodel of persistent virus infections the agent was studied in more detail. These studies showed the virus to have a diameter of 17 nm, and to contain a covalently closed circular single-stranded DNA with a molecular weight of 0.58 × 106and a main capsid polypeptide with a molecular weight of 36,000. Of the animals tested, only pigs were found to have antibodies. On the basis of these properties the virus appears to be a member of a family of animal viruses so far not encountered. We have named the virus porcine circovirus (PCV).