Prenatal pyrethroid insecticide exposure and thyroid hormone levels and birth sizes of neonates.
Prenatal pyrethroid insecticide exposure and thyroid hormone levels and birth sizes of neonates.
复制标题
产前拟除虫菊酯杀虫剂暴露与甲状腺激素水平和新生儿的出生大小。
DOI：
10.1016/j.scitotenv.2014.04.104
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kato N
中科院分区：
文献类型：
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作者：
Zhang J;Yoshinaga J;Hisada A;Shiraishi H;Shimodaira K;Okai T;Koyama M;Watanabe N;Suzuki E;Shirakawa M;Noda Y;Komine Y;Ariki N;Kato N
在先前的动物研究中，已证明拟除虫菊酯类杀虫剂具有干扰甲状腺激素的特性。在这项研究中，母亲在怀孕期间暴露于拟除虫菊酯类杀虫剂和新生儿甲状腺激素状态（全血中的游离甲状腺素（fT 4）和促甲状腺激素（TSH））和出生大小之间的关系进行了探讨，在东京的147对母亲-新生儿。在妊娠前三个月采样的母体尿液中3-苯氧基苯甲酸（3-PBA）的浓度用于拟除虫菊酯暴露评估。新生儿fT 4和TSH均在正常范围内，但1例新生儿TSH升高（但fT 4正常）。采用逐步变量选择的多元回归分析未提取母体3-PBA对新生儿fT 4和TSH具有显著性，表明母体拟除虫菊酯暴露对新生儿受试者的新生儿甲状腺激素状态无明显影响。对于出生体重和头围，选择母体3-PBA作为显著性，其具有正偏回归系数沿着其他已知会增加新生儿出生尺寸的因素（孕周或母体BMI）。尚不清楚这是否是因果关系，因为没有明显的生物学机制。
Pyrethroid insecticides have been shown to possess thyroid hormone disrupting properties in previous animal studies. In this study, the relationship between maternal exposure to pyrethroid insecticides during pregnancy and neonatal thyroid hormone status (free thyroxine (fT4) and thyroid stimulating hormone (TSH) in whole blood) and birth sizes were explored in 147 mother–neonate pairs in Tokyo. The concentration of 3-phenoxybenzoic acid (3-PBA) in maternal urine, sampled in the first trimester of gestation, was used for pyrethroid exposure assessment. Neonatal fT4 and TSH were within the normal range except for one elevated TSH (but normal fT4) in a neonate. Multiple regression analyses with stepwise variable selection did not extract maternal 3-PBA as significant for neonatal fT4 and TSH, indicating that maternal pyrethroid exposure had no apparent effect on the neonatal thyroid hormone status of the neonate subjects. For birth weight and head circumference, maternal 3-PBA was selected as significant with a positive partial regression coefficient along with other factors known to increase birth sizes of neonates (gestational weeks or maternal BMI). It was not clear if this was causal because no biological mechanism was apparent.