Odor identification in Huntington's disease patients and asymptomatic gene carriers.
Odor identification in Huntington's disease patients and asymptomatic gene carriers.
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亨廷顿病患者和无症状基因携带者的气味识别。
DOI：
10.1176/jnp.9.4.598
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Brandt,J
中科院分区：
文献类型：
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作者：
Bylsma,FW;Moberg,PJ;Doty,RL;Brandt,J
方法20名HD患者，20名临床健康个体在ITI 5处具有HD突变（阳性= CAG重复长度37），以及20名来自HD家族的个体测试为突变阴性（阴性= CAG重复长度< 34）参与了研究（表I）。两个无症状组在定量神经学检查（QNE）中的得分均在正常范围内。程序对每个受试者进行宾夕法尼亚大学神经学鉴定测试（UPSIT）。使用“刮闻法”，受试者闻一种气味（如橙子的气味），然后从四个选项中选择物质的名称。使用相同的任务格式进行图片识别测试2（PIT），其要求受试者识别UPSIT刺激的图片（例如橙子的图片）。还进行了简易精神状态检查（MMSE）。还记录了受教育年限和吸烟史（从未吸烟、戒烟、目前吸烟）。
METHODSSubjects Twenty HD patients, 20 clinically healthy individuals with the HD mutation at ITI5(Positive= CAG repeat length 37), and 20 individuals from HD families who tested negative for the mutation(Negative= CAG repeat length< 34) participated in the study(Table I). Both asymptomatic groups scored in the normal range on the Quantified Neurological Exam9 (QNE).Procedures Each subject was administered the University of Pennsylvania Smell Identification Test’#{176},”(UPSIT). Using a “scratch-and-sniff” method, subjects sniff an odorant (such as the odor of an orange) and then choose the name of the substance from among four choices. The Picture Identification Test’2 (PIT), which requires the subject to identify pictures of UPSIT stimuli(such as a picture of an orange), was administered using the same task format. The Mini-Mental State Examination”(MMSE) was also administered. Years of education and tobacco smoking history(never, stopped, current smoker) were also recorded.