Severe acute rhabdomyolysis induced by multi-agent chemotherapy for alveolar rhabdomyosarcoma in a 15-year-old female: a case report.
Severe acute rhabdomyolysis induced by multi-agent chemotherapy for alveolar rhabdomyosarcoma in a 15-year-old female: a case report.
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DOI：
10.1159/000354271
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发表时间：
2013
影响因子：
0.8
通讯作者：
Hara T
中科院分区：
文献类型：
--
作者：
Matsuzaki H;Koga Y;Suminoe A;Oba U;Takimoto T;Hara T
这是第一篇报道癌症化疗与儿童横纹肌溶解症相关的文章。一名以前健康的15岁日本女性被诊断为腺泡状横纹肌肉瘤。她接受了第一个周期的多药化疗，没有任何不良反应。然而，她在第二个周期的多药化疗（包括依托泊苷、异环磷酰胺、放线菌素D和长春新碱）后不久发生重度急性横纹肌溶解症。她的病情迅速恶化，她接受了机械通气和补液治疗。经过进一步的评估，抗癌药物被认为是横纹肌溶解症的原因。
This is the first paper to report the association of cancer chemotherapy with rhabdomyolysis in children. A previously healthy, 15-year-old Japanese female was diagnosed as having alveolar rhabdomyosarcoma. She received the first cycle of multi-agent chemotherapy without any adverse effects. However, she developed severe acute rhabdomyolysis shortly after the second cycle of multi-agent chemotherapy, which consisted of etoposide, ifosfamide, actinomycin-D and vincristine. Her condition deteriorated rapidly and she was treated with mechanical ventilation and fluid replacement. After further evaluation, anticancer drugs were thought to be responsible for the rhabdomyolysis.