Lateral gene transfers and the evolution of eukaryotes: theories and data
Lateral gene transfers and the evolution of eukaryotes: theories and data
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DOI：
10.1099/00207713-52-5-1893
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发表时间：
2002-09-01
影响因子：
2.8
通讯作者：
Katz, LA
中科院分区：
文献类型：
--
作者：
Katz, LA
可遗传物质的垂直传播是达尔文进化论的基石，但它不足以描述真核生物，特别是微生物真核生物的进化。这是因为真核细胞和真核基因组是嵌合的，通过垂直(亲代传给后代)和横向(跨物种)传播的组合进化而来。对真核生物中广泛存在的嵌合体的观察导致了对真核生物起源和多样性的新的和修订的假说，这些假说对横向基因转移(LGT)的节奏(早期和持续转移)和模式(供体和受体血统的性质)提供了具体的预测。对现有数据的分析表明，真核生物中的LGT主要分为两类：(1)从细胞器到细胞核的LGT，其中只有少数似乎发生在真核生物起源时；(2)涉及不同供体和受体血统的异常LGT。进一步检验关于真核生物起源和多样化的假设将需要来自一些不同的真核生物和原核生物的完整基因组序列，以及来自广泛的系统发育样本的靶基因序列。
Vertical transmission of heritable material, a cornerstone of the Darwinian theory of evolution, is inadequate to describe the evolution of eukaryotes, particularly microbial eukaryotes. This is because eukaryotic cells and eukaryotic genomes are chimeric, having evolved through a combination of vertical (parent to offspring) and lateral (trans-species) transmission. Observations on widespread chimerism in eukaryotes have led to new and revised hypothesis for the origin and diversification of eukaryotes that provide specific predictions on the tempo (early vs continuous transfers) and mode (nature of donor and recipient lineages) of lateral gene transfers (LGTs). Analyses of available data indicate that LGTs in eukaryotes largely fall into two categories: (1) LGTs from organelles to the nucleus, only a few of which appear to have occurred at the time of the origin of eukaryotes, and (2) anomalous LGTs involving diverse donor and recipient lineages. Further testing of hypotheses on the origin and diversification of eukaryotes will require complete genome sequences from a number of diverse eukaryotes and prokaryotes combined with sequences of targeted genes from a broad phylogenetic sample.