Incidence of Autoimmune Myasthenia Gravis in a Health Maintenance Organization in Buenos Aires, Argentina
Incidence of Autoimmune Myasthenia Gravis in a Health Maintenance Organization in Buenos Aires, Argentina
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DOI：
10.1159/000477733
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发表时间：
2017-01-01
影响因子：
5.7
通讯作者：
Rugiero, Marcelo
中科院分区：
文献类型：
--
作者：
Bettini, Mariela;Chaves, Marcelo;Rugiero, Marcelo
背景：不同的流行病学研究，特别是在欧洲，估计重症肌无力（MG）的发病密度在 1.7 至 21.3/1,000,000/人年之间；然而，来自拉丁美洲等地区的数据却很少。本研究旨在估计阿根廷布宜诺斯艾利斯获得性重症肌无力的发病率和患病率。方法：研究人群由意大利医院医疗护理计划的附属机构组成，该计划是一家位于布宜诺斯艾利斯的预付费健康维护组织。病例发现的评估方法包括对2006年1月1日至2012年12月31日的回顾性检索。结果：在发现的60例病例中，36例（60%）为女性。诊断时的中位年龄为 69 岁 (IQR 51.5-79)。诊断时的平均年龄为 63.3 岁 (SD +/- 20)。共有 28 名患者（46.7%）患有全身性 MG，32 名患者患有眼部 MG（53.3%）。 35 名患者（58.3%）有乙酰胆碱受体抗体，2 名患者（3.3%）有肌肉特异性受体酪氨酸激酶抗体。 MG 的粗发病密度 (ID) 为每 100 万人年 61.33 例 (95% CI 47.62-79.99)。阿根廷人口的调整后 ID 为每 100 万人年 38.8 (95% CI 27.09-50.51)，布宜诺斯艾利斯人口的调整 ID 为 47.49 (95% CI 34.73-60.25)。结论：获得的结果与针对其他地理区域发布的结果相似。 (C) 2017 S. Karger AG，巴塞尔
Background: Different epidemiological studies, especially in Europe, have estimated the incidence density of myasthenia gravis (MG) to range between 1.7 and 21.3/1,000,000/person-year; however, data from regions such as Latin America are scarce. This study is aimed at estimating the incidence and prevalence of acquired MG in Buenos Aires, Argentina. Methods: The study population comprised of affiliates of the Italian Hospital Medical Care Program, a prepaid health maintenance organization located in Buenos Aires. The evaluation method for case detection included a retrospective search from January 1, 2006, through December 31, 2012. Results: Of the 60 cases identified, 36 (60%) were females. The median age at diagnosis was 69 years (IQR 51.5-79). The mean age at diagnosis was 63.3 years (SD +/- 20). A total of 28 patients (46.7%) had generalized MG and 32 had ocular MG (53.3%). Thirty five patients (58.3%) had acetylcholine receptor antibodies and 2 (3.3%) had muscle-specific receptor tyrosine kinase antibodies. The crude incidence density (ID) of MG was 61.33 per 1,000,000 person-years (95% CI 47.62-79.99). The adjusted ID for the Argentinean population was 38.8 per 1,000,000 person-years (95% CI 27.09-50.51) and for the Buenos Aires population was 47.49 (95% CI 34.73-60.25). Conclusions: The results obtained are similar to those published for other geographical areas. (C) 2017 S. Karger AG, Basel