CARDIOVASCULAR RISK-FACTORS AND THE 25-YEAR INCIDENCE OF DIABETES-MELLITUS IN MIDDLE-AGED MEN - THE ZUTPHEN STUDY
CARDIOVASCULAR RISK-FACTORS AND THE 25-YEAR INCIDENCE OF DIABETES-MELLITUS IN MIDDLE-AGED MEN - THE ZUTPHEN STUDY
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DOI：
10.1093/oxfordjournals.aje.a115437
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发表时间：
1989-12-01
影响因子：
5
通讯作者：
KROMHOUT, D
中科院分区：
文献类型：
--
作者：
FESKENS, EJM;KROMHOUT, D
在祖特芬研究中，对841名中年男性进行了经典心血管危险因素（包括饮食）与非胰岛素依赖型糖尿病25年发病率之间的相关性研究。发病率为3.8/1000人-年。在单变量分析中，肩胛下和躯干皮褶厚度、体重指数（体重（kg）/身高（m）2）、吸烟、静息心率和收缩压的基线测量值与糖尿病发病率显著相关。在多变量生存分析中，也考虑了年龄、能量摄入和饮酒量，肩胛下皮褶厚度、静息心率和吸烟与糖尿病发病率独立相关。肩胛下皮褶厚度的影响在基线和随访期间无心血管疾病的受试者以及发生心血管疾病的病例中显示。吸烟仅在没有心血管疾病的男性中是一个独立的危险因素，而在心血管疾病的事件病例中，静息心率的影响更强。饮食因素和糖尿病发病率之间没有发现关联。
The association between classical cardiovascular risk factors, including diet, and the 25-year incidence of non-insulin-dependent diabetes mellitus was examined in 841 middle-aged men within the Zutphen Study. The incidence rate was 3.8/1,000 person-years. In univariate analyses, baseline measurements of subscapular and tricipital skinfold thicknesses, body mass index (weight (kg)/height (m)2), cigarette use, resting heart rate, and systolic blood pressure were significantly associated with diabetes incidence. In multivariate survival analyses also taking age, energy intake, and alcohol consumption into account, subscapular skinfold thickness, resting heart rate, and cigarette use were independently related to diabetes incidence. The effect of subscapular skinfold thickness was shown among subjects free of cardiovascular disease at baseline and during follow-up and among cases who developed cardiovascular disease. Cigarette smoking was an independent risk factor only in men who remained free of cardiovascular disease, while the effect of resting heart rate was stronger within incident cases of cardiovascular disease. No associations were found between dietary factors and diabetes incidence.