CIRCADIAN-RHYTHM OF CORTICOSTERONE IN MICE - EFFECT OF CHRONIC CONSUMPTION OF ALCOHOL
CIRCADIAN-RHYTHM OF CORTICOSTERONE IN MICE - EFFECT OF CHRONIC CONSUMPTION OF ALCOHOL
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DOI：
10.1007/bf00421118
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
MOORE, JA
中科院分区：
文献类型：
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作者：
KAKIHANA, R;MOORE, JA
本文研究了长期饮酒对DBA/2 J雄性小鼠血浆皮质酮昼夜变化的影响。在15周的酒精消耗（3.8%wt/vol的第一周和7.5%的后续周）后，酒精组表现出一个平坦的昼夜皮质酮曲线，水平之间的峰值和谷值的水对照组。在酒精治疗的第10周，酒精组的食物和液体消耗的昼夜模式仍然存在，尽管酒精组和水组之间在每6小时间隔消耗的食物和液体的绝对量有些不同。血中酒精浓度在清晨出现一个高峰，平均值为100 mg/100 ml，但其余时间的酒精浓度非常稳定，平均值为30-46 mg/100 ml。长期饮酒，即使是相对较低的浓度，似乎会影响中枢神经系统中控制ACTH释放昼夜节律的神经部位。
The effect of chronic consumption of alcohol on the circadian variations of the plasma corticosterone was investigated in DBA/2J male mice. After 15 wk of alcohol consumption (3.8% wt/vol for the 1st wk and 7.5% for subsequent weeks) the alcohol groups exhibited a flattened circadian corticosterone curve, the level being intermediate between the peak and trough values of the water control groups. The diurnal patterns of food and liquid consumption were still present at the 10th wk of alcohol treatment in the alcohol groups, although the absolute amount of food and liquid consumed at each of the 6 h intervals was somewhat different between the alcohol and water groups. The blood alcohol showed a peak at early morning with the mean of 100 mg/100 ml, but the levels of alcohol during the remaining periods were remarkably stable, the means ranging from 30-46 mg/100 ml. Chronic consumption of alcohol, even relatively low concentrations, appears to affect the neural sites in the CNS controlling the circadian rhythm of ACTH release.