Cancer-related multiple brain infarctions caused by Trousseau syndrome in a patient with metastatic colon cancer: a case report.
Cancer-related multiple brain infarctions caused by Trousseau syndrome in a patient with metastatic colon cancer: a case report.
复制标题
DOI：
10.1186/s40792-016-0217-7
复制
发表时间：
2016-12
影响因子：
0.8
通讯作者：
Baba H
中科院分区：
文献类型：
--
作者：
Akiyama T;Miyamoto Y;Sakamoto Y;Tokunaga R;Kosumi K;Shigaki H;Kurashige J;Iwatsuki M;Baba Y;Yoshida N;Baba H
与恶性肿瘤相关的血栓栓塞症称为特鲁索综合征。我们在此报告一例转移性结肠癌全身化疗期间出现特鲁索综合征的病例。一位65岁的男性多发性肝转移患者接受了直接肿瘤切除和全身化疗。在一线化疗后立即通过磁共振成像检测到多发性脑梗塞，这被认为是无效的。没有证据表明有心源性中风或颈动脉粥样硬化。虽然患者最初没有症状，但后来出现了瘫痪。尽管接受了抗凝治疗，他还是反复出现梗塞复发，并且梗塞面积随着肝转移的进展而扩大。患者的情况对晚期结肠癌的替代治疗方案没有反应。他在发现肿瘤大约11个月后去世。
Thromboembolism that occurs in association with a malignant tumor is known as Trousseau syndrome. We herein present a case of Trousseau syndrome during systemic chemotherapy for metastatic colon cancer. A 65-year-old man with multiple liver metastases underwent primary tumor resection and systemic chemotherapy. Multiple brain infarctions were detected by magnetic resonance imaging immediately after first-line chemotherapy, which was deemed ineffective. There was no evidence of cardioembolic stroke or carotid atherosclerosis. Although the patient was initially asymptomatic, he subsequently developed paralysis. Despite anticoagulant treatment, he developed repeated recurrences of the infarction, and the area of the infarction spread as the liver metastases progressed. The patient’s condition showed no response to an alternative treatment regimen for advanced colon carcinoma. He died approximately 11 months after tumor discovery.