C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes
C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes
复制标题
C2ORF40通过调节M期细胞周期基因的表达抑制乳腺癌细胞增殖和侵袭
DOI：
10.4161/epi.24626
复制
发表时间：
2013-06-01
期刊：
影响因子：
3.7
通讯作者：
Wei, Guangwei
中科院分区：
文献类型：
--
作者：
Lu, Jing;Wen, Mingxin;Wei, Guangwei
Recently, it has been suggested that C2ORF40 is a candidate tumor suppressor gene in breast cancer. However, the mechanism for reduced expression of C2ORF40 and its functional role in breast cancers remain unclear. Here we show that C2ORF40 is frequently silenced in human primary breast cancers and cell lines through promoter hypermethylation. C2ORF40 mRNA level is significantly associated with patient disease-free survival and distant cancer metastasis. Overexpression of C2ORF40 inhibits breast cancer cell proliferation, migration and invasion. By contrast, silencing C2ORF40 expression promotes these biological phenotypes. Bioinformatics and FACS analysis reveal C2ORF40 functions at G2/M phase by downregulation of mitotic genes expression, including UBE2C. Our results suggest that C2ORF40 acts as a tumor suppressor gene in breast cancer pathogenesis and progression and is a candidate prognostic marker for this disease.
