Neurobiology of schizophrenia: search for the elusive correlation with symptoms
Neurobiology of schizophrenia: search for the elusive correlation with symptoms
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DOI：
10.3389/fnhum.2012.00136
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发表时间：
2012-05-25
影响因子：
2.9
通讯作者：
Ford, Judith M.
中科院分区：
文献类型：
--
作者：
Mathalon, Daniel H.;Ford, Judith M.
在过去的半个世纪里，人类神经科学方法提供了一种在体内研究精神分裂症的方法，并确定它与大脑结构和功能的细微异常有关。然而，了解诊断所依据的临床症状的神经生物学基础的努力基本上没有成功。在本文中，我们提供了一个概述的概念和方法上的障碍，破坏了努力联系的严重程度，具体的症状，以具体的神经生物学措施。这些障碍包括小样本，可疑的可靠性和有效性的测量，药物混淆，未能区分状态和特质的影响，相关性因果关系的模糊性，以及缺乏令人信服的动物模型的特定症状来测试机制的假设来自脑症状的相关性。最后，我们提出建议，以促进建立脑症状关系的进展。
In the last half-century, human neuro science methods provided a way to study schizophrenia in vivo, and established that it is associated with subtle abnormalities in brain structure and function. However, efforts to understand the neurobiological bases of the clinical symptoms that the diagnosis is based on have been largely unsuccessful. In this paper, we provide an overview of the conceptual and methodological obstacles that undermine efforts to link the severity of specific symptoms to specific neurobiological measures. These obstacles include small samples, questionable reliability and validity of measurements, medication confounds, failure to distinguish state and trait effects, correlation-causation ambiguity, and the absence of compelling animal models of specific symptoms to test mechanistic hypotheses derived from brain-symptom correlations. We conclude with recommendations to promote progress in establishing brain-symptom relationships.