The relative configurations of azalomycins F5a, F4a and F3a
The relative configurations of azalomycins F5a, F4a and F3a
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DOI：
10.1016/j.molstruc.2012.09.024
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发表时间：
2013-03-13
影响因子：
3.8
通讯作者：
Chen, Shanjun
中科院分区：
文献类型：
--
作者：
Yuan, Ganjun;Li, Peibo;Chen, Shanjun
阿扎霉素F-5a（1）、F-4a（2）和F-3a（3）是3个36元多羟基大环内酯类化合物，具有显著的抗真菌活性。通过比较1及其降解产物的NMR谱数据与几个通用NMR数据库和已知化合物的相同片段的NMR谱数据，首次归属了1的相对构型，只是立体簇C-6-C-11至C-14-C-36的立体化学尚未确定。通过与1的核磁共振谱数据比较，确定了2和3的相对构型。(c)2012 Elsevier B. V.保留所有权利。
Azalomycins F-5a (1), F-4a (2) and F-3a (3) are three 36-membered polyhydroxyl macrolides with remarkable antifungal activity. By comparing the NMR spectral data of 1 and its degradation products with those of several universal NMR databases and identical fragments of known compounds, the relative configuration of 1 was assigned for the first time except that the stereochemistry of stereoclusters C-6-C-11 to C-14-C-36 was undefined. Moreover, the relative configurations of 2 and 3 were respectively established by comparing their NMR spectral data with those of 1. (c) 2012 Elsevier B.V. All rights reserved.