Comparison of hippocampal dendritic spines in culture and in brain
Comparison of hippocampal dendritic spines in culture and in brain
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DOI：
10.1523/jneurosci.18-14-05294.1998
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发表时间：
1998-07-15
影响因子：
5.3
通讯作者：
Stevens, CF
中科院分区：
文献类型：
--
作者：
Boyer, C;Schikorski, T;Stevens, CF
我们已经量化海马棘结构在光和超微结构水平的细胞培养物中类似于1-3周龄，在啮齿动物的大脑5和21日龄。在文化和大脑中，带有突触的棘的数量随着年龄的增长而增加，但两者的结构相似。在培养中，大约一半的突触形成在棘上，其余的形成在树突轴上。在5日龄的大脑中，大约一半的突触发生在树突轴上，到3周龄，只有大约20%的突触被发现在树突轴上，而在成年的轴突触是非常罕见的。
We have quantified hippocampal spine structure at the light and ultrastructural levels in cell cultures similar to 1-3 weeks old and in the brains of rodents 5 and 21 d old. The number of spines bearing synapses increases with age in cultures and in brain, but the structures are similar in both. In culture, about half of the synapses are formed on spines and the remainder are formed on dendritic shafts. In the 5-d-old brain, about half of the synapses occur on dendritic shafts, by 3 weeks of age only similar to 20% of synapses are found on dendritic shafts, and in the adult shaft synapses are very rare.