The Resurrection of Murahashi Coupling after Four Decades
The Resurrection of Murahashi Coupling after Four Decades
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DOI：
10.1021/acscatal.1c03564
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发表时间：
2021-10-15
期刊：
影响因子：
12.9
通讯作者：
Colacot, Thomas J.
中科院分区：
文献类型：
--
作者：
Hazra, Susanta;Seechurn, Carin C. C. Johansson;Colacot, Thomas J.
自 20 世纪 70 年代发现开创性的交叉偶联命名反应以来，涉及有机锂试剂的交叉偶联（Murahashi 偶联）已被忽视了 30 多年。由于有机锂偶联配偶体的高反应活性和低官能团耐受性，该反应被认为是一种技术上不实用的反应，其选择性较差。在这篇综述中，我们将提供有关 Murahashi 偶联复兴的全面更新，该偶联使化学家能够通过使用现代催化系统并开发适当的反应条件来克服许多困难。由于Murahashi耦合的复活主要是由于Feringa的工作而发生的，因此这种转变可以被认为是Murahashi-Feringa耦合。
Since the discovery of the pioneering cross-coupling name reactions in the 1970s, cross-coupling involving organolithium reagents (Murahashi coupling) has been neglected for more than 30 years. It was considered to be a technically nonpractical reaction based on the poor selectivity, because of the high reactivity and low functional group tolerance of the organolithium coupling partner. In this Review, we shall provide a comprehensive update on the renaissance of Murahashi coupling that enabled chemists to overcome many difficulties by using modern catalytic systems, in conjunction with the development of appropriate reaction conditions. As the resurrection of Murahashi coupling has occurred mainly due to Feringa's work, this transformation may be considered as Murahashi-Feringa coupling.