Influence of volatile anesthetics on muscarinic regulation of adenylate cyclase activity.
Influence of volatile anesthetics on muscarinic regulation of adenylate cyclase activity.
复制标题
挥发性麻醉剂对腺苷酸环化酶活性的毒蕈碱调节的影响。
DOI：
10.1016/0006-2952(90)90702-m
复制
发表时间：
1990
影响因子：
5.8
通讯作者：
Aronstam,RS
中科院分区：
文献类型：
--
作者：
Anthony,BL;Dennison,RL;Aronstam,RS
全身麻醉剂在涉及毒蕈碱胆碱能受体的自主控制下对心血管功能的几个方面具有深远的影响[1]，并且有理由怀疑心脏中胆碱能传递的中断有助于麻醉作用某些方面的发展。我们已经证明挥发性麻醉剂改变鸟嘌呤核苷酸调节大鼠心脏和脑干膜中毒蕈碱激动剂结合的能力，表明挥发性麻醉剂破坏毒蕈碱受体-G蛋白相互作用[2-4]。还发现氟烷可降低腺苷酸环化酶活性的毒蕈碱控制[5]。本研究旨在确定毒蕈碱调节腺苷酸环化酶活性的中断是否是挥发性麻醉药的共同特性。我们的研究结果表明，毒蕈碱控制腺苷酸环化酶被许多挥发性麻醉药抑制。
General anesthetics have profound effects on several aspects of cardiovascular performance under autonomic control involving muscarinic cholinergie receptors [1], and it is reasonable to suspect that a disruption of cholinergic transmission in the heart contributes to the development of certain aspects of anesthetic action. We have demonstrated that volatile anesthetics alter the ability of guanine nucleotides to regulate muscarinie agonist binding in both rat cardiac and brainstem membranes, indicating that volatile anesthetics disrupt muscarinic receptor-G protein interactions [2-4]. Halothane was also found to decrease muscarinic control of adenylate cyclase activity [5]. The present studies were designed to determine if disruption of muscarinic modulation of adanylate cyclase activity is a common property of volatile anesthetics. Our results demonstrate that muscarinic control of adenylate cyclase is inhibited by numerous volatile anesthetics.