Biomedical Applications of Organometal–Peptide Conjugates
Biomedical Applications of Organometal–Peptide Conjugates
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DOI：
10.1007/978-3-642-13185-1_8
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发表时间：
2010
影响因子：
7.3
通讯作者：
N. Metzler‐Nolte
中科院分区：
文献类型：
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作者：
N. Metzler‐Nolte
肽非常适合作为靶向载体，用于定向递送基于金属的药物或用于生物医学研究的探针。本章描述了制备具有医学意义的肽与共价结合的金属络合物的缀合物的合成策略。使用的肽包括神经肽（脑啡肽、神经肽Y、神经降压素）、摄取肽（达特和聚-Arg）和细胞内定位序列。近年来，通过固相肽合成（SPPS）技术将各种各样的过渡金属配合物连接到这些肽上。作为SPPS方案的一部分，金属络合物可以连接到树脂上的肽。或者，金属络合物可以作为合成后修饰与肽连接。任何一种策略的优点和缺点进行了讨论。生物医学应用包括放射性药物应用、抗癌和抗菌活性、作为靶向CO-释放分子的金属-肽缀合物以及生物传感器应用中的金属-肽缀合物。
Peptides are well suited as targeting vectors for the directed delivery of metal-based drugs or probes for biomedical investigations. This chapter describes synthetic strategies for the preparation of conjugates of medically interesting peptides with covalently bound metal complexes. Peptides that were used include neuropeptides (enkephalin, neuropeptide Y, neurotensin), uptake peptides (TAT and poly-Arg), and intracellular localization sequences. To these peptides, a whole variety of transition metal complexes has been attached in recent years by solid-phase peptide synthesis (SPPS) techniques. The metal complex can be attached to the peptide on the resin as part of the SPPS scheme. Alternatively, the metal complex may be attached to the peptide as a postsynthetic modification. Advantages as well as disadvantages for either strategy are discussed. Biomedical applications include radiopharmaceutical applications, anticancer and antibacterial activity, metal–peptide conjugates as targeted CO-releasing molecules, and metal–peptide conjugates in biosensor applications.