Insights into Campylobacter jejuni-induced Guillain-Barré syndrome from the Lewis rat model of experimental allergic neuritis.
Insights into Campylobacter jejuni-induced Guillain-Barré syndrome from the Lewis rat model of experimental allergic neuritis.
复制标题
从实验性过敏性神经炎的 Lewis 大鼠模型深入了解空肠弯曲菌诱发的格林-巴利综合征。
DOI：
10.1086/513787
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Vriesendorp,FJ
中科院分区：
文献类型：
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作者：
Vriesendorp,FJ
实验性变态反应性神经炎(EAN)被认为是格林-巴利综合征(GBS)的体内模型，并在Lewis大鼠身上进行了广泛的研究。免疫反应的细胞和体液成分都与周围神经的炎性脱髓鞘有关，这是EAN的特征。人们认识到空肠弯曲菌感染是GBS中常见的先天事件，特别是它与抗神经节苷脂抗体和原发轴索神经病的关系，提出了许多关于具体发病机制的问题。而C。空肠杆菌可引起鸡的急性运动神经病，证实了C。对于空肠感染和急性神经病，没有从这个动物模型中获得详细信息。来自与Lewis大鼠EAN效应相相关的实验研究的启示可能与总有机碳相关。对空肠诱导的GBS进行了讨论。
Experimental allergic neuritis (EAN) is considered the in vivo model of Guillain-Barré syndrome (GBS) and has been extensively studied in the Lewis rat. Both cellular and humoral components of the immune response are implicated in the inflammatory demyelination of peripheral nerves that characterizes EAN. The recognition ofCampylobacter jejuniinfection as a frequent antecedent event in GBS, and in particular its association with anti-ganglioside antibodies and a primary axonal neuropathy, has raised many questions about the specific disease mechanisms involved. WhileC. jejunican produce an acute motor neuropathy in chickens, confirming the relationship betweenC. jejuniinfection and acute neuropathy, no detailed information is available from this animal model. Insights from experimental studies relating to the effector phase of Lewis rat EAN that may be relevant toC. jejuni-induced GBS are discussed.