ABERRANT NEUROFILAMENT PHOSPHORYLATION IN ALZHEIMER-DISEASE
ABERRANT NEUROFILAMENT PHOSPHORYLATION IN ALZHEIMER-DISEASE
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DOI：
10.1073/pnas.82.12.4274
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
ULRICH, J
中科院分区：
文献类型：
--
作者：
STERNBERGER, NH;STERNBERGER, LA;ULRICH, J
阿尔茨海默缠结，尽管他们的位置在[人类]神经元胞体，反应免疫细胞化学与单克隆抗体的磷酸化表位的神经丝。正常的胞体不含磷酸化的神经丝。斑块和缠结中的异常磷酸化似乎在很大程度上局限于神经丝中许多可用位点中的单个磷酸化位点。阿尔茨海默病损害涉及负责神经丝中不同位点磷酸化的特定激酶内的不平衡。
Alzheimer tangles, despite their location in [human] neuronal perikarya, react immunocytochemically with monoclonal antibodies to phosphorylated epitopes of neurofilaments. Normal perikarya do not contain phosphorylated neurofilaments. The aberrant phosphorylation in both plaques and tangles seems to be largely restricted to individual phosphorylation sites among the many sites available in neurofilaments. The Alzheimer lesion involves an imbalance within specific kinases responsible for phosphorylation of different sites in neurofilaments.