The prognostic significance of VEGF-C and VEGF-A in non-Hodgkin lymphomas
The prognostic significance of VEGF-C and VEGF-A in non-Hodgkin lymphomas
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DOI：
10.1080/10428190802706665
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发表时间：
2009-01-01
影响因子：
2.6
通讯作者：
Yavuz, Sinan
中科院分区：
文献类型：
--
作者：
Paydas, Semra;Seydaoglu, Gulsah;Yavuz, Sinan
血管生成和淋巴管生成对于恶性造血肿瘤的增殖和存活很重要。本研究的目的是确定血管生成和淋巴管生成在淋巴瘤发展中的预后作用。为此，我们通过免疫组织化学方法对 177 例病例中的 VEGF-A 和 VEGF-C 进行了研究。 34% 和 61% 的样本中 VEGF-C 和 VEGF-A 呈阳性。 VEGF-C 和 VEGF-A 表达之间存在良好的相关性 (p=0.0001)。 VEGF-C（+）和（-）和/或VEGF-A（+）和（-）病例的临床预后指标没有显着差异。 VEGF-A（+）和VEGF-C（+）病例的总生存率（OS）比阴性病例短（分别为p=0.03和p=0.0005）。在表达 VEGF-A 和 VEGF-C 的侵袭性淋巴瘤中，OS 显着缩短，但在惰性淋巴瘤中则不然。 Cox回归分析结果显示，VEGF-A和VEGF-C表达是独立的预后参数（对于（+）病例，OR：2.6，95% CI：1.3-5.0）。总之，VEGF-C 和 VEGF-A 在 NHL 病例中分别有 34% 和 61% 呈阳性。 VEGF-C 和 VEGF-A 之间的显着相关性表明，淋巴管生成在淋巴瘤的发病机制中很重要，如血管生成所示。 VEGF-C 和/或 VEGF-A 表达的存活率显着缩短表明血管生成和淋巴管生成在临床结果中很重要。淋巴瘤细胞中的自分泌 VEGF-A 和 VEGF-C 串扰在淋巴瘤生物学中很重要，用抗血管生成/抗淋巴管生成药物抑制这些信号以及与化疗免疫治疗方案相结合将在这些病例中更有用。
Angiogenesis and lymphangiogensis are important in the proliferation and survival of the malignant hemeopoietic neoplasms. The aim of this study is to determine the prognostic role of angiogenesis and lymphangiogenesis in the development of lymphoma. For this aim, VEGF-A and VEGF-C were explored by immunohistochemistry in 177 cases. VEGF-C and VEGF-A were found to be positive in 34 and 61% of the samples. There was a good correlation between VEGF-C and VEGF-A expression (p=0.0001). The clinical prognostic indicators were not significantly different between VEGF-C (+) and (-) and/or VEGF-A (+) and (-) cases. Overall survival (OS) rate was shorter in cases with VEGF-A (+) and VEGF-C (+) cases than with negative cases (p=0.03 and p=0.0005, respectively). The OS was significantly shorter in aggressive lymphomas expressing VEGF-A and VEGF-C but not in indolent lymphomas. The results of Cox regression analyses showed that VEGF-A and VEGF-C expressions are independent prognostic parameters (OR: 2.6, 95% CI: 1.3-5.0 for both (+) cases). In conclusion, VEGF-C and VEGF-A were positive in 34 and 61%, respectively, of the cases with NHL. The significant correlation between VEGF-C and VEGF-A suggests that lymphangiogenesis is important in the pathogenesis of lymphomas as shown in angiogenesis. The significantly shorter survival rates of VEGF-C and/or VEGF-A expressions indicate that angiogenesis and lymphangiogenesis are important in clinical outcome. Autocrine VEGF-A and VEGF-C crostalks in lymphoma cells are important in lymphoma biology and inhibition of these signals with anti-angiogenic/anti-lymphangiogenic drugs and combination with chemo-immunotherapy regimens will be more useful in these cases.