Analysis of clinical characteristics and prognostic factors for angioimmunoblastic T-cell lymphoma
Analysis of clinical characteristics and prognostic factors for angioimmunoblastic T-cell lymphoma
复制标题
DOI：
10.1007/s12185-015-1763-7
复制
发表时间：
2015-06-01
影响因子：
2.1
通讯作者：
Sawada, Kenichi
中科院分区：
文献类型：
--
作者：
Kameoka, Yoshihiro;Takahashi, Naoto;Sawada, Kenichi
血管免疫母细胞T细胞淋巴瘤（AITL）是一种独特的外周T细胞淋巴瘤实体，具有独特的临床特征和不良预后。其临床特征和预后因素尚未明确。为了阐明AITL的临床特征和预后特征，我们进行了一项多中心回顾性研究。入组了五十六例患者。患者年龄中位数为68岁。肿瘤细胞免疫组化检查显示CD10和T细胞标志物阳性，染色体检查检测到几种类型的异常。超过80%的患者在诊断时表现为晚期疾病和预后评分较差。高比例的患者在诊断时表现出伴随的B症状、脾肿大和肝肿大。5年总生存率（OS）为48%，无进展生存率为25%。单因素分析显示，较高的年龄，发热，体力状态差，贫血，低白蛋白水平是OS的不良预后因素。除了这些因素，IPI和PIT也预测OS。多因素分析表明，只有低水平的血清白蛋白是OS的一个显着的预后因素。血清白蛋白可能是AITL的重要预后因素之一。需要进一步的研究来证实这些结果。
Angioimmunoblastic T-cell lymphoma (AITL) is a distinct peripheral T-cell lymphoma entity exhibiting peculiar clinical features and poor prognosis. Its clinical characteristics and prognostic factors are not well established. To clarify the clinical characteristics and prognostic features of AITL, we conducted a multicenter, retrospective study. Fifty-six patients were enrolled. The median patient age was 68 years. Immunohistochemical examinations of tumor cells showed positivity for CD10 and T-cell markers, and chromosomal examination detected several types of abnormalities. More than 80 % of patients show advanced disease at diagnosis and poor prognostic scores. A high proportion of patients showed accompanying B symptoms, splenomegaly, and hepatomegaly at diagnosis. The 5-year overall survival (OS) rate was 48 % and progression-free survival was 25 %. Univariate analysis revealed higher age, fever, poor performance status, anemia, and low albumin level to be poor prognostic factors for OS. In addition to these factors, both IPI and PIT were also predictive of OS. Multivariate analysis indicated only a low level of serum albumin to be a significant prognostic factor for OS. Serum albumin may be one of the important prognostic factors for AITL. Further investigation is needed to confirm these results.