TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel.
TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel.
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TRPM7 是体积敏感的外向整流阴离子通道的重要调节剂。
DOI：
10.1016/j.jphs.2021.04.006
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Okada Y
中科院分区：
文献类型：
--
作者：
Numata T;Sato-Numata K;Hermosura MC;Mori Y;Okada Y
温柔的触摸，如抚摸皮肤，产生一种愉快的感觉，这是由一个罕见的感觉神经元的子集，表达马斯相关的G蛋白偶联受体B4（MrgprB4）在小鼠检测。我们研究了三叉神经节和背根神经节中的少数MrgprB4阳性神经元，其中大多数对瞬时受体电位锚蛋白1（TRPA 1）激动剂敏感，但对TRPV 1、TRPM 8或TRPV 4激动剂不敏感。缺乏MrgprB4并不影响无毛足底和有毛脸颊的伤害性疼痛或瘙痒行为。虽然丙酮诱导的后爪冷感相关的行为没有改变，丙酮应用或蔗糖飞溅到脸颊的不愉快的感觉行为显着增强Mrgprb4基因敲除小鼠以及TRPA1基因敲除小鼠。这些结果表明，三叉神经元中的MrgprB4与TRPA 1合作产生愉快的感觉，而不是伤害或寒冷的感觉。愉快的感觉可以通过MrgprB4调节脸颊上的不愉快的感觉。
Gentle touch such as stroking of the skin produces a pleasant feeling, which is detected by a rare subset of sensory neurons that express Mas-related G protein-coupled receptor B4 (MrgprB4) in mice. We examined small populations of MrgprB4-positive neurons in the trigeminal ganglion and the dorsal root ganglion, and most of these were sensitive to transient receptor potential ankyrin 1 (TRPA1) agonist but not TRPV1, TRPM8, or TRPV4 agonists. Deficiency of MrgprB4 did not affect noxious pain or itch behaviors in the hairless plantar and hairy cheek. Although behavior related to acetone-induced cold sensing in the hind paw was not changed, unpleasant sensory behaviors in response to acetone application or sucrose splash to the cheek were significantly enhanced in Mrgprb4-knockout mice as well as in TRPA1-knockout mice. These results suggest that MrgprB4 in the trigeminal neurons produces pleasant sensations in cooperation with TRPA1, rather than noxious or cold sensations. Pleasant sensations may modulate unpleasant sensations on the cheek via MrgprB4.