Metabolic engineering: enabling technology for biofuels production

Metabolic engineering: enabling technology for biofuels production
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代谢工程:生物燃料生产的支持技术

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发表时间:
2012
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通讯作者:
G. Stephanopoulos
G. Stephanopoulos
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作者:
Mitchell Tai;G. Stephanopoulos

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生物燃料行业正在迅速发展,其目标是提供石油产品的可持续燃料替代品。然而,在限制目前的生物燃料技术作为一种可行的替代品方面存在两个挑战:(1)原料成本和(2)燃料质量。代谢工程显示出克服这两个挑战的潜力,能够以可持续和环境友好的方式将更便宜的原料生物转化为改进的燃料。代谢工程是系统地尝试使用广泛的跨学科工具和策略来理解,设计和工程细胞代谢网络。它正在迅速成为下一代生物燃料开发背后的使能技术。当前研究的几个例子展示了代谢工程如何开始为实现有前途的生物燃料技术提供新颖和创造性的解决方案:生产高级链醇,发酵木质纤维素材料和生产脂肪酸衍生物。© 2012约翰威利父子有限公司.
The biofuels industry is rapidly growing with the goal of providing a sustainable fuel alternative to petroleum products. However, two challenges persist in limiting current biofuels technologies as a viable alternative: (1) the cost of feedstock and (2) the quality of the fuel. Metabolic engineering shows the potential to overcome these two challenges, enabling the bioconversion of cheaper feedstocks into improved fuels in a sustainable and environmentally friendly manner. Metabolic engineering is the systematic attempt to understand, design, and engineer cellular metabolic networks using a wide range of interdisciplinary tools and strategies. It is rapidly emerging as the enabling technology behind the development of the next generation of biofuels. Several examples of current research demonstrate how metabolic engineering has begun to contribute both novel and creative solutions toward bringing promising biofuel technologies to fruition: production of higher chain alcohols, fermentation of lignocellulosic material, and production of fatty acid derivatives. © 2012 John Wiley & Sons, Ltd.