Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure?
Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure?
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DOI：
10.1007/s00404-013-3020-8
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发表时间：
2014-03-01
影响因子：
2.6
通讯作者：
El-Refaeey, Abdel-Aziz A.
中科院分区：
文献类型：
--
作者：
Fawzy, Muhammad;El-Refaeey, Abdel-Aziz A.
目的：探讨口服强的松龙联合LMW肝素在既往不明原因植入失败的ICSI患者中的应用效果。在一所大学教学医院和一所私人诊所进行了一项准随机对照试验。共有334个周期（既往原因不明，一次或两次ICSI尝试失败的妇女）被随机分配接受标准治疗或联合泼尼松龙（20mg /天），从卵巢刺激的第一天开始，LMW肝素1mg /kg/天开始，除标准治疗外，卵母细胞取出后1天。两组的平均年龄、先前试管婴儿失败的次数和基础FSH水平具有可比性。研究组与对照组的受孕率和着床率有显著差异。口服强的松龙联合低分子肝素可能对先前不明原因的植入失败的妊娠和着床率有显著影响。
To study the effect of combined oral prednisolone and LMW heparin in ICSI in women with previously unexplained, failed implantation.A prospective quasi-randomized, controlled trial was conducted at a university teaching hospital and a private practice setting. A total of 334 cycles (women with previously unexplained, failed one or two ICSI attempts) were assigned randomly to receive standard treatment or combined prednisolone (20 mg/day), starting on the first day of ovarian stimulation and LMW heparin 1 mg/kg/day starting 1 day after oocyte retrieval in addition to standard treatment.The mean age, number of previously failed IVF attempts, and basal FSH levels were comparable between both groups. The pregnancy and the implantation rates were significantly different between the study and control groups.A combination of oral prednisolone and low molecular weight heparin may have a significant effect on pregnancy and implantation rates in prior unexplained, failed implantation.