KI-mediated radical multi-functionalization of vinyl azides: a one-pot and efficient approach to β-keto sulfones and α-halo-β-keto sulfones
KI-mediated radical multi-functionalization of vinyl azides: a one-pot and efficient approach to β-keto sulfones and α-halo-β-keto sulfones
复制标题
KI 介导的乙烯基叠氮化物的自由基多功能化：一锅法高效制备β-酮砜和α-卤-β-酮砜的方法
DOI：
10.1039/c6qo00756b
复制
发表时间：
2017-06-01
影响因子：
5.4
通讯作者：
Yu, Yongping
中科院分区：
文献类型：
--
作者：
Chen, Wenteng;Liu, Xingyu;Yu, Yongping
描述了乙烯基叠氮化物与磺酰肼的无过渡金属氧化偶联反应。该工艺实现了乙烯基叠氮化物在碘化钾和过氧化氢t-丁基存在下的氧化多官能团化，选择性地产β-酮砜和α-环-β-酮砜，收率高，对官能团的耐受性好。
Transition metal-free oxidative coupling of vinyl azides with sulfonyl hydrazines is described. This radical process realized oxidative multi-functionalization of vinyl azides in the presence of potassium iodide and t-butyl hydroperoxide, selectively yielding β-keto sulfones and α-halo-β-keto sulfones in good to excellent yields with a wide tolerance of functional groups.