Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats.
Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats.
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发表时间：
2007-03
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通讯作者：
D. Saha;Animita C. Saha;G. Malik;M. Astiz;E. Rackow
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作者：
D. Saha;Animita C. Saha;G. Malik;M. Astiz;E. Rackow
我们将35只雄性Sprague-Dawley大鼠分为7组，并使用以下方案之一麻醉每组：氯胺酮50 mg+甲苯噻嗪5 mg;氯胺酮75 mg+甲苯噻嗪5 mg;戊巴比妥45 mg;和Telazol 30、40、50和60 mg/kg;根据需要使用补充剂量。每30 min测量一次呼吸频率、心率、平均动脉压、心脏指数和卒中指数，持续4 h。Telazol组显示麻醉持续时间呈剂量依赖性增加。氯胺酮和戊巴比妥组的麻醉持续时间显著短于任何Telazol剂量。Telazol组的心率呈剂量依赖性降低，但这些组的总体心率高于氯胺酮和戊巴比妥组。Telazol 40和50组的平均动脉压显著高于戊巴比妥和较高剂量氯胺酮组，但低于Telazol 60组。用Telazol麻醉的所有动物显示出最高的心脏指数，氯胺酮居中，戊巴比妥最低; Telazol 50组的心脏指数高于Telazol 30或戊巴比妥组。戊巴比妥组表现出最低的中风指数，而氯胺酮治疗的动物有一个中间中风指数。在选择麻醉方案或比较不同研究的数据时，必须考虑麻醉药对心血管参数的不同影响。在我们的模型中，Telazol 40和50组似乎表现出最少的心血管不良反应。
We allocated 35 male Sprague-Dawley rats into 7 groups and anesthetized each by using one of the following regimens: ketamine 50 mg+xylaxine 5 mg; ketamine 75 mg+xylazine 5 mg; pentobarbital 45 mg; and Telazol 30, 40, 50, and 60 mg/kg; supplemental doses were used as required. Respiratory rate, heart rate, mean arterial pressure, cardiac index, and stroke index were measured every 30 min for 4 h. The Telazol groups showed a dose-dependent increase in duration of anesthesia. Duration of anesthesia was significantly shorter for the ketamine and pentobarbital groups than for any of the Telazol doses. Heart rate showed a dose-dependent decrease among the Telazol groups, but overall heart rate in these groups was higher than in the ketamine and pentobarbital groups. Mean arterial pressure in the Telazol 40 and 50 groups was significantly higher than the pentobarbital and higher ketamine groups yet lower than that of the Telazol 60 group. Overall animals anesthetized with Telazol showed the highest cardiac index, ketamine intermediate, and pentobarbital the lowest; cardiac index was higher in the Telazol 50 group than in either the Telazol 30 or pentobarbital groups. The pentobarbital group exhibited the lowest stroke index, whereas ketamine-treated animals had an intermediate stroke index. These differing effects of anesthetics on cardiovascular parameters must be considered when choosing an anesthesia regimen or comparing data from different studies. In our model, the Telazol 40 and 50 groups appeared to exhibit the fewest adverse cardiovascular effects.