COMPARISON OF THE ANTITUSSIVE EFFECTS OF CODEINE PHOSPHATE 20 MG, DEXTROMETHORPHAN 30 MG AND NOSCAPINE 30 MG USING CITRIC ACID-INDUCED COUGH IN NORMAL SUBJECTS
COMPARISON OF THE ANTITUSSIVE EFFECTS OF CODEINE PHOSPHATE 20 MG, DEXTROMETHORPHAN 30 MG AND NOSCAPINE 30 MG USING CITRIC ACID-INDUCED COUGH IN NORMAL SUBJECTS
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DOI：
10.1007/bf00568199
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发表时间：
1979-01-01
影响因子：
2.9
通讯作者：
HUGHES, DTD
中科院分区：
文献类型：
--
作者：
EMPEY, DW;LAITINEN, LA;HUGHES, DTD
在 18 名健康受试者中测定了可待因 20 mg、右美沙芬 30 mg、诺斯卡品 30 mg 和安慰剂对柠檬酸引起的咳嗽的保护作用。药物差异发生在摄入药物后 2 1/2 小时，但不是在 1 1/4 小时。只有 20 mg 可待因比安慰剂具有更强的镇咳作用，但 30 mg 右美沙芬也与 20 mg 可待因没有差异。该技术可以为新的潜在镇咳化合物在人体中的活性提供有用的筛选测试。
Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in 18 healthy human subjects. Drug differences occurred at 2 1/2 h following ingestion of the drugs, but not at 1 1/4 h. Only codeine 20 mg had a greater antitussive action than placebo, but dextromethorphan 30 mg also did not differ from codeine 20 mg. This technique may offer a useful screening test for the activity of new potential antitussive compounds in man.