Influence of glutardialdehyde on dentin demineralization in vitro and in vivo.
Influence of glutardialdehyde on dentin demineralization in vitro and in vivo.
复制标题
戊二醛对体外和体内牙本质脱矿的影响。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
G. Rölla
中科院分区：
文献类型：
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作者：
J. Arends;B. Ogaard;J. Ruben;J. Wemes;G. Rölla
本文报道了戊二醛（GDA）对人牙本质的体外脱矿作用和用Ogaard正畸带环系统对牙本质的体内脱矿作用。结果显示，在pH = 3.6下施加2%GDA溶液2分钟显著减少体外和体内牙本质脱矿。显微放射照相术显示病变深度和体外矿物质损失分别减少20%和36%。2周后，在体内脱矿作用相同的百分比减少分别为60%和44%。GDA对牙本质的作用机制尚不明确。据推测，体外作用是由于牙本质基质的表面交联导致钙和磷酸盐转运出牙本质减少。在体内，另外的作用可能是GDA对斑块或斑块积聚的相当短期的影响。本文的结果表明，戊二醛是一个有趣的代理考虑在减少根龋。
In this paper the results are presented on the action of glutardialdehyde (GDA) on the in vitro demineralization of human dentin and on the in vivo demineralization of dentin using the Ogaard orthodontic banding system. The results show that a 2 min application of a 2% GDA solution at pH = 3.6 reduces dentin demineralization in vitro and in vivo substantially. Microradiography shows a percentage reduction of lesion depth and mineral loss in vitro of 20 and 36%, respectively. After 2 wk in vivo demineralization the same percentage reductions are 60 and 44%, respectively. The mechanism of action of GDA on dentin is not certain yet. Presumably the in vitro action is due to surface cross-linking of the dentin matrix causing reduced Ca and phosphate transport out of the dentin. In vivo an additional effect may be a rather short term influence of GDA on plaque or on plaque accumulation. The results of this paper indicate that glutardialdehyde is an interesting agent to consider in the reduction of root caries.