Expression of the ets-1 proto-oncogene in human breast carcinoma:: Differential expression with histological grading and growth pattern
Expression of the ets-1 proto-oncogene in human breast carcinoma:: Differential expression with histological grading and growth pattern
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DOI：
10.14670/hh-20.119
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发表时间：
2005-01-01
影响因子：
2
通讯作者：
Sekine, I
中科院分区：
文献类型：
--
作者：
Katayama, S;Nakayama, T;Sekine, I
原癌基因ets-1是一种已知的转录因子，可以控制许多基因的表达，并被认为在细胞生长、分化和肿瘤侵袭中发挥作用。我们对137例乳腺癌进行免疫组化检测，比较不同组织类型浸润性癌中Ets-1的表达程度。Ets-1在正常乳腺上皮和非侵袭性癌中均未表达。137例乳腺癌中，Ets-1蛋白阳性104例（83.2%）。组织学上，浸润性导管癌表达免疫阳性，肿瘤细胞中Ets-1染色强烈。浸润性导管癌中Ets-1表达与Bloom-Richardson分级相关(p
The proto-oncogene, ets-1, is a transcription factor known to control the expression of a number of genes and has been postulated to play a role in cell growth, differentiation and tumour invasion. We examined 137 cases of breast carcinoma by immunohistochemistry and compared the degree of Ets-1 expression among the different histological types of invasive carcinomas. Ets-1 was not expressed in the normal breast epithelium nor in noninvasive carcinomas. Among the 137 breast carcinoma cases, 104 (83.2%) showed positive staining for the Ets-1 protein. Histologically, invasive ductal carcinomas expressed immunopositivity with intense staining for Ets-1 in the tumour cells. Ets-1 expression correlated with Bloom-Richardson grading in invasive ductal carcinoma (p