Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells.
Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells.
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DOI：
10.1016/j.molonc.2010.06.009
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发表时间：
2010-10
影响因子：
6.6
通讯作者：
Witte ON
中科院分区：
文献类型：
--
作者：
Goldstein AS;Stoyanova T;Witte ON
组织干细胞与上皮性癌症有关，包括前列腺癌。关于干细胞和癌症，仅依赖于功能研究有三个相关问题：1。成人器官中有组织再生干细胞吗？2. 组织再生细胞可以作为转化的目标吗？3. 原发肿瘤是否含有肿瘤增殖细胞（肿瘤干细胞）？我们将回顾有关这些关键问题的最新文献，以提供原始细胞和前列腺癌之间的直接联系。
Tissue stem cells have been linked to cancers of epithelial origin including the prostate. There are three relevant issues concerning stem cells and cancer that rely solely on functional studies: 1. Are there tissue-regenerating stem cells in the adult organ? 2. Can tissue-regenerating cells serve as targets for transformation? 3. Do primary tumors contain tumor-propagating (cancer stem) cells? We will review the recent literature with respect to these critical issues to provide a direct link between primitive cells and prostate cancer.
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影响因子：
2.8
作者：
ABRAHAMSSON, PA;FALKMER, S;GRIMELIUS, L
通讯作者：
GRIMELIUS, L
影响因子：
5.3
作者：
Belandia, B;Powell, SM;Parker, MG
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Parker, MG
影响因子：
11.2
作者：
Collins, AT;Berry, PA;Maitland, NJ
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Maitland, NJ
影响因子：
21.3
作者：
Asselin-Labat, Marie-Liesse;Sutherland, Kate D.;Visvader, Jane E.
通讯作者：
Visvader, Jane E.
影响因子：
6.2
作者：
Chen, GP;Shukeir, N;Rabbani, SA
通讯作者：
Rabbani, SA