Clot-selective coronary thrombolysis with tissue-type plasminogen activator.
Clot-selective coronary thrombolysis with tissue-type plasminogen activator.
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DOI：
10.1126/science.6602378
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发表时间：
1983-06
期刊：
影响因子：
56.9
通讯作者：
Bergmann;K. Fox;M. Ter-pogossian;B. Sobel;D. Collen
中科院分区：
文献类型：
--
作者：
Bergmann;K. Fox;M. Ter-pogossian;B. Sobel;D. Collen
冠状动脉溶栓是一种可以消除急性心肌梗塞后遗症的干预措施，通过静脉注射凝块选择性组织型纤溶酶原激活剂，在狗身上 10 分钟内完成。除了诱导血栓溶解外，这种有前途的纤溶剂还可以恢复中间代谢和营养性心肌血流，可通过正电子断层扫描进行无创检测，而不会诱导全身纤溶状态。
Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.