Metabolic profiling of elite athletes with different cardiovascular demand
Metabolic profiling of elite athletes with different cardiovascular demand
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DOI：
10.1111/sms.13425
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发表时间：
2019-07-01
影响因子：
4.1
通讯作者：
Elrayess, Mohamed A.
中科院分区：
文献类型：
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作者：
Al-Khelaifi, Fatima;Donati, Francesco;Elrayess, Mohamed A.
精英运动员的高强度运动会导致心血管系统的生理变化，以应对心搏量和血压的增加，统称为心血管需求（CD）。本研究旨在比较高与低/中度CD精英运动员的代谢差异，并揭示其潜在的代谢途径，作为评估精英运动员健康，表现和恢复的潜在生物标志物。采用基于非靶向代谢组学的质谱结合超高效液相色谱法，对来自不同运动学科的495名优秀运动员（118名高CD运动员和377名低/中度CD运动员）的血清样本进行代谢分析。结果表明，含有花生四烯酸的DAG富含高CD以及支链氨基酸、纤溶酶原、磷脂酰胆碱和磷脂酰乙醇胺，这可能表明高CD组心血管疾病的风险增加。低/中CD组中γ-谷氨酰氨基酸和谷胱甘肽代谢增加，表明比高CD组更有效的氧化应激清除机制。这是精英运动员的第一个最全面的代谢分析提供了证据，表明具有不同CD的运动员显示出独特的代谢特征，反映了能量生成和氧化应激，并可能使高CD组处于心血管疾病的更高风险中。进一步的研究是必要的，以确认和验证的结果在其他运动组的潜在混杂因素有关的有限的可用信息的参与者。
Intensive exercise of elite athletes can lead to physiological alterations in the cardiovascular system in response to increased stroke volume and blood pressure, known collectively as cardiovascular demand (CD). This study aimed to compare metabolic differences in elite athletes with high vs low/moderate CD and to reveal their underlying metabolic pathways as potential biomarker signatures for assessing health, performance, and recovery of elite athletes. Metabolic profiling of serum samples from 495 elite athletes from different sport disciplines (118 high CD and 377 low/moderate CD athletes) was conducted using non-targeted metabolomics-based mass spectroscopy combined with ultra-high-performance liquid chromatography. Results show that DAGs containing arachidonic were enriched in high CD together with branched-chain amino acids, plasminogens, phosphatidylcholines, and phosphatidylethanolamines, potentially indicating increased risk of cardiovascular disease in the high CD group. Gamma-glutamyl amino acids and glutathione metabolism were increased in low/moderate CD group, suggesting more efficient oxidative stress scavenging mechanisms than the high CD group. This first most comprehensive metabolic profiling of elite athletes provides an evidence that athletes with different CD show a unique metabolic signature that reflects energy generation and oxidative stress and potentially places the high CD group at a higher risk of cardiovascular disease. Further studies are warranted for confirmation and validation of findings in other sport groups in light of potential confounders related to limited available information about participants.