A systematic review and meta-analysis of premature mortality in bipolar affective disorder.
A systematic review and meta-analysis of premature mortality in bipolar affective disorder.
复制标题
对双相情感障碍早死亡的系统综述和荟萃分析。
DOI：
10.1111/acps.12408
复制
发表时间：
2015-06
影响因子：
6.7
通讯作者：
Osborn DP
中科院分区：
文献类型：
--
作者：
Hayes JF;Miles J;Walters K;King M;Osborn DP
审查并完成估计双相情感障碍（BPAD）全因死亡率和病因特异性死亡率的标准化死亡率（SMR）的Meta分析。原因特异性死亡率分为自然和非自然原因。这些亚组进一步分为循环系统、呼吸系统、肿瘤和感染原因以及自杀和其他暴力死亡。使用随机效应Meta分析计算总结SMR。通过亚组分析和Meta回归检查异质性。系统检索发现31项研究符合纳入标准。全因死亡率的SMR总结= 2.05（95% CI 1.89-2.23），但异质性较高（I 2 = 96.2%）。这种异质性无法通过发表日期、队列规模、数据收集的十年中期、人群类型或地理区域来解释。非自然死亡总结SMR = 7.42（95% CI 6.43-8.55），自然死亡= 1.64（95% CI 1.47-1.83）。自杀SMR = 14.44（95% CI 12.43-16.78），其他暴力死亡SMR = 3.68（95% CI 2.77-4.90），循环系统疾病死亡= 1.73（95% CI 1.54-1.94），呼吸系统疾病= 2.92（95% CI 2.00-4.23），感染= 2.25（95% CI 1.70-3.00）和肿瘤= 1.14（95% CI 1.10-1.21）。尽管存在相当大的异质性，但所有汇总的SMR估计值和绝大多数个体研究都显示，与一般人群相比，BPAD的死亡率升高。这对于所研究的所有死亡原因都是正确的。
To review and complete meta‐analysis of studies estimating standardised mortality ratios (SMRs) in bipolar affective disorder (BPAD) for all‐cause and cause‐specific mortalities. Cause‐specific mortality was grouped into natural and unnatural causes. These subgroups were further divided into circulatory, respiratory, neoplastic and infectious causes, and suicide and other violent deaths. Summary SMRs were calculated using random‐effects meta‐analysis. Heterogeneity was examined via subgroup analysis and meta‐regression. Systematic searching found 31 studies meeting inclusion criteria. Summary SMR for all‐cause mortality = 2.05 (95% CI 1.89–2.23), but heterogeneity was high (I 2 = 96.2%). This heterogeneity could not be accounted for by date of publication, cohort size, mid‐decade of data collection, population type or geographical region. Unnatural death summary SMR = 7.42 (95% CI 6.43–8.55) and natural death = 1.64 (95% CI 1.47–1.83). Specifically, suicide SMR = 14.44 (95% CI 12.43–16.78), other violent death SMR = 3.68 (95% CI 2.77–4.90), deaths from circulatory disease = 1.73 (95% CI 1.54–1.94), respiratory disease = 2.92 (95% CI 2.00–4.23), infection = 2.25 (95% CI 1.70–3.00) and neoplasm = 1.14 (95% CI 1.10–1.21). Despite considerable heterogeneity, all summary SMR estimates and a large majority of individual studies showed elevated mortality in BPAD compared to the general population. This was true for all causes of mortality studied.