Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: Evidence of inhibitory deficits
Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: Evidence of inhibitory deficits
复制标题
DOI：
10.1176/appi.ajp.157.10.1660
复制
发表时间：
2000-10-01
影响因子：
17.7
通讯作者：
Braff, DL
中科院分区：
文献类型：
--
作者：
Cadenhead, KS;Swerdlow, NR;Braff, DL
目的：精神分裂症谱系障碍患者在感觉运动门控方面存在缺陷，通过脉冲前惊吓反应抑制来评估。作者假设精神分裂症患者的非精神分裂症亲属也会有脉冲前抑制缺陷，从而反映了感觉运动门控缺陷的遗传易感性。方法：25名对照受试者。采用声惊吓范式对23例精神分裂症患者、34例精神分裂症患者亲属和11例分裂型人格障碍患者进行测试。结果：与对照组相比，精神分裂症患者及其亲属和分裂型人格障碍受试者AIL的脉冲前抑制明显减少，且这种缺陷在右眼眨眼前脉冲抑制措施中更为明显。结果表明，精神分裂症谱系障碍患者，包括分裂型人格障碍患者和精神分裂症患者的先证者、其亲属和精神分裂症患者的前脉冲抑制(感觉运动门控)存在遗传传递缺陷。
Objective: Patients with schizophrenia spectrum disorders have been shown to have deficits in sensorimotor gating as assessed by prepulse inhibition of the startle response. The authors hypothesized that nonschizophrenic relatives of patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genetically transmitted susceptibility to sensorimotor gating deficits.Method: Twenty-five comparison subjects. 23 patients with schizophrenia, 34 relatives of the schizophrenic patients, and 11 subjects with schizotypal personality disorder were assessed in an acoustic startle paradigm. The eye-blink component of the startle response was assessed bilaterally by using electromyographic recordings of orbicularis oculi.Results: The patients with schizophrenia, their relatives, and subjects with schizotypal personality disorder ail had reduced prepulse inhibition relative to comparison subjects, and these deficits were more evident in measures of right eve-blink prepulse inhibition. Comparison subjects demonstrated greater right versus left eye-blink prepulse inhibition, whereas the probands, their relatives, and subjects with schizotypal personality disorder showed less asymmetry of prepulse inhibition.Conclusions: These data suggest a genetically transmitted deficit in prepulse inhibition (sensorimotor gating) in patients with schizophrenia spectrum disorders, including subjects with schizotypal personality disorder and relatives of patients with schizophrenia.