Age-Associated Alteration in Innate Immune Response in Captive Baboons
Age-Associated Alteration in Innate Immune Response in Captive Baboons
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DOI：
10.1093/gerona/glr146
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发表时间：
2011-12-01
影响因子：
5.1
通讯作者：
White, Gary L.
中科院分区：
文献类型：
--
作者：
McFarlane, Dianne;Wolf, Roman F.;White, Gary L.
狒狒是研究人类炎症反应的理想模型，因为它们在生理和免疫学上与人类相似；然而;人们对年龄如何影响狒狒的免疫功能知之甚少。我们试图确定狒狒是否表现出与人类相似的与年龄相关的先天免疫变化。年龄与血清c反应蛋白和白细胞介素-6升高有关，但白细胞介素-10浓度没有变化（n = 120只狒狒）。随着年龄的增长，未受刺激的外周血单个核细胞以及免疫（脂多糖）刺激后的细胞因子释放增加。当检测全血时，脂多糖刺激和未刺激的样本都显示出与年龄相关的白细胞介素-6反应增加，尽管未刺激的细胞因子反应与外周血单个核细胞相比有所减少。肿瘤坏死因子- α反应与年龄无关。脂多糖刺激全血细胞因子反应与血清DHEA-S浓度呈负相关，与tgf - β浓度呈正相关。
Baboons are an ideal model for studies of human inflammatory response due to their physiological and immunological similarities to people; however; little is known about how age affects immune function in the baboon. We sought to determine if baboons show age-related innate immune changes similar to that described in people. Age was correlated with increased serum C-reactive protein and interleukin-6 or, however, no change in interleukin-10 concentration was observed (n = 120 baboons). Cytokine release from unstimulated peripheral blood mononuclear cells as well as following immune (lipopolysaccharide) stimulation increased with age. When whole blood was assayed, both lipopolysaccharide stimulated and unstimulated samples showed an age-related increase in interleukin-6 response, although the unstimulated cytokine response was reduced compared with that observed in peripheral blood mononuclear cells. Tumor necrosis factor-alpha response was not related to age. Cytokine response in lipopolysaccharide-stimulated whole blood was negatively correlated with serum DHEA-S concentration and positively correlated with TGF-beta concentration.