Reduced frontal white matter integrity in cocaine dependence: A controlled diffusion tensor imaging study
Reduced frontal white matter integrity in cocaine dependence: A controlled diffusion tensor imaging study
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DOI：
10.1016/s0006-3223(01)01355-5
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发表时间：
2002-06-01
影响因子：
10.6
通讯作者：
Rotrosen, JP
中科院分区：
文献类型：
--
作者：
Lim, KO;Choi, SJ;Rotrosen, JP
背景：体内磁共振研究发现，可卡因依赖与脑白质T2信号高信号和代谢物异常有关。功能神经成像研究表明，慢性使用可卡因主要与额叶局部脑血流和脑葡萄糖代谢水平的缺陷有关；然而，可卡因依赖对额叶WM微结构的影响(如果有的话)尚不清楚。因此，我们试图检测可卡因依赖对额WM完整性的影响。方法：采用扩散张量成像技术，在前连合-后连合平面(AC-PC)上方10 mm、上方5 mm、上方0 mm和下方5 mm四个平面上检测额区WM完整性。结果：可卡因依赖者AC-PC面额部各向异性(FA)显著降低，AC-PC面下5 mm处FA降低，提示WM整合素减少。结论：这些发现与可卡因依赖涉及眶-额叶连接改变的假说相一致，这可能与本病的决策缺陷有关。生物精神病学2002；51：890-895(C)2002生物精神病学学会。
Background: In vivo magnetic resonance studies have found that cocaine dependence is associated with T2 signal hyperintensities and metabolite abnormalities in cerebral white matter (WM). Functional neuroimaging studies have suggested that chronic cocaine use is primarily associated with frontal lobe deficits in regional cerebral blood flow and brain glucose metabolism levels; however, the effects of cocaine dependence, if any, on frontal WM microstructure are unknown. Thus, we sought to examine the effects of cocaine dependence on frontal WM integrity.Methods: Diffusion tensor imaging was employed to examine the WM integrity of frontal regions at four levels: 10 mm above, 5 mm above, 0 mm above, and 5 mm below the anterior commissure-posterior commissure (AC-PC) plane. The fractional anisotropy (FA) of 12 cocaine-dependent patients and 13 age-similar control subjects was compared.Results: The cocaine-dependent patients had significantly reduced FA in the frontal WM at the AC-PC plane and a trend toward reduced FA at 5 mm below the A C-PC plane, suggestive of reduced WM integrin, in these regions.Conclusions: These findings were consistent with the hypothesis that cocaine dependence involves alterations in orbitofrontal connectivity, which may be involved in the decision-making deficits seen in this disorder. Biol Psychiatry 2002;51:890-895 (C) 2002 Society of Biological Psychiatry.